«As a "virus", HIV does not exist.
Under "HIV" I mean only the parasitic program, that causes AIDS.
AIDS is real, but it falls out of the scope of activity of infectious diseases and Microbiology.
The full theory of AIDS and the solution of AIDS problem were described by me in 1989».
|Story of how a civil engineer Makarov developed and notarize physiotherapy treatment for AIDS
|PUBLICATION AT THE INTERNET-PORTAL "KURIERWEB.COM"
|About the exit at the American internet-portal "Kurierweb.com" Makarov's article "Diseases, such as "Chain Reaction" (Article Three)
|PUBLICATION IN THE "PRAVDA.RU" NEWSPAPER
|Hog-wash: The Russian scientist discovered a cure for AIDS 10 years ago. He was found insane ("PRAVDA.RU" newspaper willfully reprinted my article from the internet-portal "Kurierweb.com")
|ARTICLE ONE (second translation): Cancer and AIDS can be defeated by the "method of black drawer"?
|This my first article, published in "Kurierweb.com", tells the story of the issue and describes my method of treatment of AIDS
|ARTICLE TWO (second translation): Thirteen and a half years laterS02... 2003
|The article explains the effectiveness of hyperthermia for the treatment of several diseases
|ARTICLE THREE (second translation): Diseases of "Chain Reaction-type"
|The article gives a detailed rationale and description of the program schemes of immune protection and HIV programs
|ARTICLE FOUR (second translation): On the theory of AIDS
|Rationale for the use of hyperthermia in medicine from the viewpoint of solid state physics. Reply to journalist Leitner.
|DENIS Vdovenko's article
|Perm journalist wrote a nice article about my method of treatment of AIDS and about my world priority in full hyperthermia
|ON MY FOLLOWERS
|Here was talked about how many I got followers in the application of full hyperthermia against cancer and AIDS, and that none of them referred to me...
Here is a my correspondence with experts from around the world on
On my expectations "war" with the professionals and about the
end of the debates.
|ARTICLE FIVE: THEORY OF DISEASES
It compares the effectiveness of treatment for people shamans
and modern doctors.
|Some reputable scientists have recognized that AIDS - error
Article-interview with a doctor Irina Sazonova with arguments that the viral
theory of AIDS has no scientific evidence.
|ARTICLE SIX: AIDS - AN OPEN DOOR INTO THE KINGDOM OF THE DEAD
AIDS - a specially made-up illness for the "population control"
|DECEPTION IN THE SELFISH INTERESTS
|Here is the information about how respectable professor, Souvernev A.V., from selfish motives a little "forgotten" about the scientific ethics
|MY HISTORY OF HYPERTHERMIA
|Excursion into the history of hyperthermia, which I spent at health funds Libraries of USA, UK and Australia
|BETWEEN SCYLLA AND CHARYBDIS
|On the possibility of defeat AIDS without the help of hyperthermia
AIDS is called the "plague of the twentieth century." Tens of thousands of scientists around the world are seeking the means to cure. Why is it every year it turns out that "things are there"? As a reason of this, in my opinion, there are three ones. Perhaps you thought that many "moneyed men" and "medical scientists" have decided to deny my recommendations and to "wipe me to powder" as amateurism, as an unheard of insolence and insult against them? No way!
The first reason is that many moneyed interest, who moves money to the drug development, it is advantageous to a cure for AIDS has not been found as long as possible - this allows them to monitor the situation and to receive profits on the principle of "divide and conquer."
The second reason is that due to prevailing practices in medicine, the cause of any internal disease, the usual doctors are looking for at a chemical or biological level.
The third reason - many young and respectable doctors "create a fog" to do his personal career and good money.
I dare say that the cause of AIDS - a "software error of the organism", which can be transmitted from person to person by means of "path of living blood". Back in 1989 I presented my revolutionary point of view on this issue in letters sent in 4 Academy of Science - the result was zero. In 2003, I sent the relevant e-mails and articles about 500 addresses of medical professionals and scientists around the world (in English and Russian languages) - the result was almost the same. Why? Because "questions of the clan is above all..."
Those who wish to get acquainted with my thoughts on this subject (English-language article "Physiotherapy treatment for AIDS and cancer diseases) may follow this link: http://sciteclibrary.ru/eng/catalog/pages/4773.html
Sergey Makarov (Posted: 05/15/2006 to the site "Unknown", the forum "AIDS and Humanity").
Weekly «Sovershenno Sekretno» («Top Secret»), № 2, 1989, p. 16
«We must remember: when we hide something from others we hide it also from ourselves», — wrote Academician P.L. Kapitsa, thinking back in the 30-ies about the "exorbitant and harmful secretness" in science.These scientist's arguments, published in the journal "Chemistry and Life, are still valid today.
— A scientific truth and achievement if they are not widely utilized, can not be recognized as achievement in science. This - as hidden in the earth minerals, which then become worth things when they are retrieved, and when they are used.
— Secret scientific achievement is equivalent to its absence. Secret condition of any thing is similar to the muscles that atrophy for lack of activity.
1) Making secrets leads to inhibition of science, as retards the development of those issues where interbreed different areas. These problems and are most advanced.
2) Making secrets excludes public scrutiny and debate, and promotes pseudoscience, idleness, bureaucratic regime.
3) Making secrets reduces the level of scientific work, as people have reduced incentive to carry it out. (Rafael, which would have hide all of his works in the roll and not felt the people's impression about his creations, perhaps couldn't grow and develop.)
4) Making secrets not lead to anything as it is essentially impossible in full. … By making secrets we harm ourselves more than our enemies.
5) Making secrets creates a monopoly in the scientific work and destroys healthy competition.
When our science will be really advanced, it will not need to make secrets.
Nobel Prize in Physics.
1. The first person was infected with AIDS by sexual contact with a monkey. HIV does not need any of input infections for its working in the body. HIV works on the principle of chain reaction, moving from the periphery closer to the center, which produces lymphocytes (in particular, to the thymus).
2. In the semen HIV (human immunodeficiency virus) is not present.
3. HIV is usually transmitted with the help of friction due to mixing of live blood of two people (in the vagina or in rectum).
4. HIV does not have a material carrier, it is the program.
5. Work system of immune defense consists not in the destruction of foreign viruses, bacteria, fungi, protozoa, etc. (As it is officially adopted), but in binding them by a special program with specifically produced in the body lymphocytes, such as T-helper cells, with subsequent release of the product that connection from the body (such as diarrhea).
6. HIV "enjoys" the ability of T-helper cells to forming stable bonds, so it substitutes for the PID (program of immune defense of human) and connects the pairs of T-helper cells among themselves and sends them into the waste.
1. Why do some people die quickly from AIDS, while others may live for decades? On this, the 4-th paragraph I should tell more detailed. The idea that by means of the increasing the body temperature the organism counteracts the illness is not new. I have this statement too, no doubt. The question, however, must be retarded at the three points:
Response. HIV by annihilating the lymphocytes, is forcing the body to reproduction them more intensively. If the rate of lymphocytes reproduction is greater than the rate of their HIV "devouring", provided that an excess of lymphocytes is enough to fight against infections (which, incidentally, enter into our bodies with every breath and every portion of food), then the person can live a very long time. HIV, except for "devouring" lymphocytes, not applies itself to anything. If the body is weak, the whole mass of lymphocytes is used for HIV's consuming, without any their remainders for the fighting against external infections, so then the external infections quickly move a man to the grave.
2. Why among 100% of AIDS patients, only 10% are women?
Response. The sexual contact a male with a male is perversion. In this case, and the genitals and rectum obtain microtrauma, entailing mixing of blood and, as a consequence, the transmission of AIDS contagion from one organism to another. Sexual intercourse a man and a woman is usually more natural. Nature at the same time takes care of vaginas lubrication to avoid abrasions of genitals. Therefore, when the man has sex with a woman (and with a good lubricant!) AIDS is not transmitted because there are absence of mutual contacts of live blood.
3. Why AIDS is transmitted through a syringe and is not transmitted through blood-sucking insects?
Response. Blood as it is known is able to be living tissue for some time, even outside the body (remember the blood transfusion), so that HIV in such blood for some time (up to the ending of lymphocytes) continues to "work". If such blood enters into another person (accidentally or intentionally), HIV continues its "work" in the new body. Unlike syringe blood-sucking insects are not just simple vessels: after the blood sucking, they immediately begin its recycling. During the time that passes from one bite, for example, a mosquito, till the moment, when the mosquito will bite another man, human blood inside the mosquito will not be a normal live blood, so HIV is not stored in it.
If only HIV could have a material carrier, this carrier from one bite till another one could, in principle, keep a viable form inside a mosquito.
I think this list of questions and answers every logically thinking person is able to continue now without any difficulty...
So what follows from all this? To answer this question, we present the list of only first external manifestation of AIDS.
1. Diarrhea (associated with each other T-helpers are rapidly eliminated from the body).
2. Human weight loss (due to frequent diarrheas and dehydration of body).
3. Swollen lymph nodes (are rapidly activated the endocrine glands for the producing protective antibodies to replace those killed by HIV).
4. The sharp body temperature rising.
— Temperature is rising in which parts of human's body, does the temperature rises uniformly; If the body is fighting against HIV by means of the raising body temperature, it is logical to assume that there is a specific value of the temperature at which a chain reaction of HIV stops. If HIV does not have any material carrier (HIV is only the ideal program), then after it stopping once, this program will not be able to continue its action (remember the chain reaction of falling dominoes, which were arranged closely each other). It is imperative to warm up all the blood in man's body, because only after that the program wouldn't continue its action after lowering body temperature.
— The temperature rises by means of what resource of energy (whether it is sufficient);
— To what level we must increase the temperature for fight with this particular disease.
1. Build a chamber with a volume for the entire body of human, which creates microwave field in entire its volume (frequency, probably is not essential, for the beginning we must use the same frequency as in the devices of UHF-therapy: 800-1000 kHz). If the method will be very rewarding, then in the future, apparently, should be built the camera not in the form of a box, but as a big tube with the diameter for a man's height (similar to a magnetic ring in the airport). The length of the pipe-chamber we choose experimentally. The idea is that a person enters one end of the continuously operating UHF-pipe-chamber, but exits the other end. More feeble (painful) people will pass the pipe slower, healthier - faster. Thus, in the continuously operating camera each person will spend on the processing of his body by microwave field as much time as required at a specific level of health of a particular organism.
2. Place the whole person into this chamber.
3. By means of slowly increasing the intensity of the field to bring the temperature of the human body till 44 degrees Celsius and to sustain it at this temperature for about 1 minute (it is better if the person in the camera will move a little).
4. Then gently decrease the intensity of the field and release a healthy person.
Sergey Makarov, engineer
September 27, 1989
The Main infectionist of Leningrad,
the leader of scientific-educational-practical
affiliation “AIDS and AIDS-associated infections”,
the head of communicable diseases department
with a course AIDS in Leningrad GIDUV (medical institute), professor,
the secretary of commission on AIDS preventive maintenance
of the “Lensovet’s executive committee”
June 25, 1990
(Published on website www.KURIERWEB.com on January 10, 2003)
While he was in one village during the trip, he had somehow caught the infection of black smallpox. At that time was an epidemic of this disease and nothing strange in the fact of he became diseased was not. I wonder what followed after that. Gilyarovsky asked the inhabitants where to find a good healer. He got the answer. When he came to the witch doctor, he asked: "Old man, can you help me get rid of black smallpox?" The old man looked at Gilyarovsky by long, appraising look and said: «If you have enough money, you must buy a burqa and a horse, in a burga must sit at a horse and by gallop move at any direction without stopping. When a horse will fall because of fatigue, buy the second one and gallop on, when the second horse will fall, buy the third one and gallop on. When will fall the third horse, you will be healthy». Gilyarovsky complied with all that said the old man. When dropped the third horse, rider, who over the road lost 16 kilograms, was completely cured of black smallpox.
(English Version was published on website www.KURIERWEB.com on February 3, 2003)
«… peripheral vasodilatation in process of total body hyperthermia originates from the interaction of nitric oxide with some hypothetical neurotransmitter that occurs in conditions of total body hyperthermia. This statement needs to be checked …» Naturally, all the mechanisms to clarify before the end is probably impossible. However, a pity if the person moves forward only to the touch, not having "even a compass" in his hands. Such motion may continue for decades and centuries. Namely this, based on his previous experience, and predicts to humanity Robert Siliciano, a professor at Johns Hopkins in Baltimore, Maryland. He believes that an effective means of AIDS not be found in the next 70 years ("Deutsche Welle", July 16, 2002, article "Modern fighting methods against AIDS").
«Mechanisms leading to hemodynamic instability, are not completely clear».
the prize was awarded to them for "genius scientific idea!". "Imagine this: it turns out that the cause of cancer, obviously, is in ourselves, and the role of external factors boils down to this, that only to press a button" - said Professor Garton ("Izvestia" newspaper of 11.10.1989, article "Controversy around the opening of the winners "). Is not that a brilliant illustration of work of the starting mechanism for diseases such as "Chain Reaction"!
February 16, 2003
May 23, 1989
February 8, 1991
(Published on website www.KURIERWEB.com on February 21, 2003)
“Nobody ever explained to me about how HIV can cause AIDS”.
Kari Myullis, the Nobel Prize in Chemistry for 1993
“The influence of the media, the pressure of special groups of people, the interests of individual pharmaceutical companies, the efforts of the establishment to implement the control of AIDS has led to a complete loss of contacts of official science with other analytical and open-minded medical scientists. This happened after the unproven HIV/AIDS hypothesis received 100% of research funds, while all other hypotheses were ignored".
Etienne de Harvey, professor of pathology at the University of Toronto
“…becoming more and more apparent that no HIV, but some other factors must be brought to the theory of AIDS…”
Richard Strohman, University of California, Berkeley
March 19, 2003
put the whole person into a special cell created the UHF field in its volume, to bring the temperature of the human body to 44 degrees Celsius and sustain it at this temperature for about 1 minute and then gradually reduce the intensity of the field and release the person, who must be healthy. Then this Makarov's method was partially appreciated by A.G. Rakhmanova - the main chief of infectious diseases in Leningrad. However, she expressed some doubts that the method can be used for the full cure of AIDS, since the viral particles are not only in blood cells of humans, but also penetrate into the genetic apparatus of other cells, kill which is impossible without destroying the whole organism.
Afterword. One of the first assessment of my fight against AIDS gave my ex-wife, she authoritatively called my work in this direction as "protivospidnaya bredyatina", because of this, I caused in her mind a "a loss of all the respect"
I recall that a similar perception of the scientific activities of her husband once announced the wife of Dmitri Mendeleev, when he created his periodic law, which then led to the periodic table of elements.
It is good, that the same about "different people have different opinions" and that, for example, a journalist Vdovenko opinion is not the views of my ex-wife.
1. USSR Academy of Sciences I sent the results to my respected magazine "Zhorovje" ("Health"), as evidenced by the documents shown below
2. USSR Academy of Medical Sciences
3. Academy of Sciences of the RSFSR
4. Academy of Sciences of the Latvian SSR
Fortunately, their patents and licenses ALL MY FOLLOWERS (including the author of the method of "optimal resonance hyperthermia" Professor Chekurov V.P.) EXECUTE MUCH LATER than I notarize "My conclusions" and sent my newsletters. I hope that this fact will ever be seen and checked by official authorities. It is noteworthy that in the Soviet Union, Russia, USA and other countries there is a ban to medical practice for people who had not received formal medical education. Perhaps this is correct (I, for example, such practices do not do). But why should those who believe that they are "cool specialists" in medicine, consider beneath their dignity TO DISCUSS new methods of treatment? Is the main reason here is that this method offered an "amateur"? And if the terminally ill need help, he too would reject it from the "amateur" in a time when "cool professionals" have spat at him and turned away from the patient? The question, as they say, "rhetorical" and the answer is not in favor of "cool professionals."
|The man from Holland believes that about me and my method of treatment Mitar Tarabich wrote in his prophecies in the XIX century
|The fact that Bill Gates is not interested in medical research aimed at fighting AIDS
|British physician believes that before me, no one delved so fundamentally to the problem of AIDS
|German AIDS-dissident does not agree that my treatment of AIDS will bring someone to benefit
|Portuguese doctor is sure: AIDS - this is a common infection of the blood, ie, AIDS does not exist
|In Israel engineer's wife has AIDS and is in urgent need treatment
|Indonesian doctors are very interested in my method of treating AIDS
|About my contacts with Russian experts on the topic of AIDS treatment
|As I responded to the appeal of journalist Khabarov "to join in the fight against AIDS"
|How Novosibirsk International Medical Center "offered me a co-operation"
|"AIDS infosait" administrator confessed his powerlessness to publish my material about AIDS
|Go to the top of page
"The whole world will be plagued by a strange disease
and nobody will be able to find a cure;
everybody will say I know, I know,
because I am learned and smart,
but nobody will know anything.
People will think and think, but they will not be able to find the right cure,
which will be, with God's help, all around them, and in themselves."
"Wise men will appear in the Orient
and their wisdom will cross all seas and frontiers,
but people will not trust this wisdom for long time,
and this real truth they will proclaim for a lie."
"There will be many learned men who will think
through their books that they know and can do everything.
They will be the great obstacle for this realisation [self-knowledge],
but once men get this knowledge, then people will see
what kind of delusion it was when they listened to their learned men.
When that happens, people will be so sorry
that they didn't discover it before,
because this knowledge is so simple..."
(From the predictions of the XIX century Serbian prophet Mitar Tarabich (1829 - 1899))
Dear Sergei!(My answer)
I can't understand your theory completely, partly because i'm not an engineer, partly because i know too little about immunology, and partly because of the not-so-good english in which it [the translation] is written*.
But it is my belief already that illnesses in general have more to do with psychic 'programming', and beliefs of people, than with viruses. And as i find more and more about the world we live in, i can more and more believe in intentional "mass hypnosis", as you say.
Regarding AIDS as such, do you know about theories that not only does HIV not cause AIDS, but that there is no AIDS at all? From all that i have read about it, this is the best explanation of "how AIDS works".
For starters on this subject, i can warmly recommend a three-part series of Jon Rappoport. Please check this, it is an eye-opener!
Go to http://www.stratiawire.com/, apply for a free (gratis) supscription so you can read articles, and then go to Archives and then enter "AIDS hoax" in the "Search articles by keyword" box. You will get a list with these articles on top of the list:
THE DEPOPULATION AGENDA
DEPOPULATION AND HIV---PART TWO
"WE HAD TO DISCREDIT PETER DUESBERG"
It is best to read them in this order (they will be listed in reverse order). After those three, check others too. You will get even more results if you then enter just "AIDS" as the keyword. But first do it this way, for introduction. Especially part two is interesting, which describes how the HIV fraud has come to be, in words of one of the people who made it happen.
Finally, another confirmation that you are right in general, i have in another source, which you maybe could find a bit strange, but i'll tell you nevertheless. In 19th century Serbia, in a small village on Tara mountain, there lived two illiterate peasants, Milos and Mitar Tarabich, often called Brothers Tarabich, but in fact they were uncle and nephew. Now, they used to have 'visions' of the future, and they described many things in future in unbelievable detail. Of course, they fellow villagers considered them crazy. They couldn't read or write, but their godfather was a (pravoslavni) priest, and although he himself wasn't totally sure if they are god-people or just crazy, he was writing their sayings down. They described, for example, world wars, Tito, cars, telephone, radio, TV, space-travel and many more things. Between other things they said:
"The whole world will be plagued by a strange disease and nobody will be able to find a cure; everybody will say I know, I know, because I am learned and smart, but nobody will know anything.
People will think and think, but they will not be able to find the right cure, which will be, with God's help, all around them, and in themselves."
Also, in more places than one, they said that "learned men" (dogmatic scientists) will be a great obstacle to many important and life-saving knowledges.
If you want to know more about them and their prohecies, you can see some excerpts at:
Sergei, this is what i had to say to you! You are of course free to respond with any thoughts you might have about all this. In general, as i said, i strongly support you and wish you all the best in your research and thinking. I think it is very important that more people with open mind think about solutions to the world's problems, as that will make sure that solutions be found sooner... And official science is becoming more and more dogmatic, just like what happened to Church in centuries after Christ. Science is our civilization's official religion, and like any religion, after it becomes institutionalized, with time it becomes more and more an obstacle to things it was supposed to help.
Keep up the good work (and thinking) and best regards,
P.S. You should really give your text to a good translator if you want it to reach english speaking audience! The way it is now, it is really hard to understand, and it will put off many readers, before they read the whole text! And i think it would be A GREAT PITY!
"Never believe anything until it has been officially denied."[Blazenko Karesin, http://arkzin.com/competitor]
Hello, Blazenko Karesin!(I have not received a reply to this email, because I soon moved to Latvia)
I have read your letter from March 25 with great pleasure. I have read also all papers about AIDS from a Rapoport’s site, which one you recommended to me. I have translated all this to Russian. I also have read closely all stuffs about the Tarabich “brothers” predictions and has kept to itself repetitions of these stuffs.
To me would like to know more about you. If you could, write to me a little about itself: as you live, about your work, age, formation, hobby etc.
You have an Ukrainian surname, I think. What is its history?
«Wise men will appear in the Orient and their wisdom will cross all seas and frontiers, but people will not trust this wisdom for long time, and this real truth they will proclaim for a lie.»
Say me, please: you really trust, what Tarabich’s predictions is relates to me? Whether have you still any interesting information on it?
I wait for your answer!
Sergey Makarov (email@example.com)
February 2, 2003Response to my letter to Bill Gates I'm waiting until now.
Dear Mr. Bill Gates:
I've heard a lot about your work towards improving the health of mankind.
Minister of Health and Human Services Secretary Tommy Thompson said recently that the fight against HIV and AIDS "is more important than the war on terrorism."
Only after that I decided to tell you personally about my physiotherapy method for treating AIDS, which, in my opinion, show us 100 percent efficiency in the fight against AIDS. Currently, this information is published in Russian:
A few days later, the same information will be there also published in English.
However, I now can provide you with basic information and in Russian, and English (in my own translation): see the ZIP-file attached to this letter.
A few days ago (01/28/2003) I sent my information to Stephanie Jones, the coordinator of your fund. He said to me: the Bill & Melinda Gates Foundation is not going to make any attempt in the direction of AIDS treatment. This news surprised me. That's why I decided to write you this letter. Let us join our efforts in the fight for the future of humanity!
I am waiting for your reply.
Sergey Makarov (Russian engineer who works in high technology now)
SERGEYFrom: ANGLESEYESCO@aol.com To: firstname.lastname@example.org
I have had a quick look at the articles mentioned in your e-mail message, but I haven't studied them properly yet. How did you hear of me?
My opinion on HIV and AIDS is as follows:
HIV has never been isolated, and its existence is only an hypothesis. There is no test for HIV that is specific to HIV, and the causes for a positive result to the HIV test are many, for example pregnancy or prior pregnancy, antibodies to many diseases, blood transfusion, etc.
AIDS is a condition where a patient has a certain serious illness and tests positive for HIV. The causes of these illnesses were known long before HIV and AIDS were "discovered", for example the sick patients have been injecting drugs, or received blood transfusions, or have poor immune systems from living in developing countries and being exposed to many diseases, or have taken the antiviral (or AIDS) drugs.
Most of the people who disagree with the orthodox view on HIV and AIDS, including myself, believe that HIV does not exist and that AIDS is not a true condition; instead they believe that many people who test positive for HIV have nothing wrong with them, and that those patients who have been diagnosed with AIDS and suffer from illnesses due to a poor immune system have other logical explanations for their poor immune systems.
This may explain the poor response that you have received to your theories about AIDS; the people who do not believe in the orthodox view on HIV and AIDS do not believe in AIDS, and so believe that there is no AIDS condition to be treated.
It is true that many people suffer from a poor immune system, and perhaps they would benefit from treatment to improve their immunity. Some people benefit by simply not continuing to take or inject drugs, others recover by better diets etc.
As I haven't read your articles in detail, I am not sure if the treatment you propose is for AIDS or for poor immune systems. If the treatment you propose is for AIDS, then I will probably not take it seriously as I believe that AIDS does not exist.
I hope that I have been of some help to you. I will read your articles soon and write to you again with my comments. You could write to me to tell me how you heard of me.
Thanks, Adrian Williams,
Location: Bangor, United Kingdom, 17 Jan '03)
SERGEYFrom: "john kirkham" (email@example.com) to Sergey Makarov (firstname.lastname@example.org)
I am sorry that I have not contacted you sooner about your articles. I have moved house, my wife has had a baby and I have been very busy.
I have had no education or training in medicine, and I don't work in medicine. Therefore it is very difficult for me to tell you if your Physiotherapeutic AIDS-treatment method makes sense or if it would work, and it would be impossible for me to test the treatment.
I am going to forward your articles to another person who perhaps could understand the medical treatment better. When I looked today at the website http:/kurierweb.com/Publications/, I couldn't find any reports in English, so I don't know if your reports are still on that website. Have you got any more reports you would like me to study?
Dear Dr. MakarovMy answer to John Kirkham (email@example.com),
My name is John Kirkham and I am an AIDS dissident. I got your email address from Adrian Williams. Although I adhere to the AIDS theories of Dr Heinrich Kremer I am writing to you because I am open to other ideas on AIDS, I know that you have engaged in recent correspondence with Stefan Lanka (do you have his email by the way?) and I would like to see how your ideas fit in with his.
Although I did not manage to make much sense of your piece About the AIDS Theory because of the language barrier, your theory seems to involve fundamental physical processes rather than an exotic viral device, this appeal to fundamental processes is where genuine scientific enquiry should start, this never happened with the HIV hypothesis.
Many otherwise intelligent people selectively switch off their critical faculties when it comes to HIV/AIDS. This is easy to do because their position is superficially plausible and there is a huge amount of superficial validation of their position because it supports a huge industry.
They do not consider alternative explanations for AIDS which the "shoddy" science of HIV has been unable to discount. HIV/AIDS suits a large number of political and commercial interests. Bill Gates for example is heavily invested in the pharmaceutical industry so it is in his interest to promote HIV/AIDS, he also shares the population control agenda for Africa that the West has pursued for a long time.
I consider AIDS to be a genuine condition but one not caused by HIV. You will have heard of the principle of Occams Razor. The HIV hypothesis does not conform to Occams Razor. For example, recent discoveries concerning the role of nitric oxide gas in immune regulation show beyond doubt that AIDS can be accounted for without the need to assume a viral agent. The whole premise for HIV as this agent is ridiculous anyway. Could you please get in touch and expound upon your theory of AIDS?
I would expect hyperthermia to be effective against some "AIDS defining" diseases but not as a result of an anti HIV effect. The observation that "HIV RNA" goes down is what would be expected as the increased temperature increases the activity of nucleases, it will also increase the activity of many other beneficial enzymes. The body naturally uses its own type of self-induced hyperthermia to fight infection and we would expect clinical improvement independent of "HIV".  The observation that "HIV infected" T cells are more labile can be attributed to them already being more oxidatively damaged.
P.S. Please look at my website www.geocities.com/pharmharm
Dear Mr. Kirham,
reply to your letter of July 23. I apologize for the delay in replying, but I just could not answer earlier because of heavy loads at work.
In my response, at first I'll follow the text of your letter (do not forget that) and then tell you something new.
You're probably not right: in April this year I corresponded with Michael Leitner of Germany, although he at that time was very busy preparing for publication of his new book. Communication was fairly brief. I got the impression that he is not open to other ideas as you are.
Yet to my article responded a gay doctor from Portugal, but he admitted that he had no doubt in the absence of the disease called "AIDS". He was confident that the AIDS is taking the usual blood poisoning.
Bill Gates, who often donates money to various medical problems, too, as I understood, "is not open to new ideas", as my letter to him remained unanswered.
I really like the principle of Occam's razor. I often use it to test my new ideas. I totally agree with you that the HIV hypothesis is not consistent with the principle of Occam's razor.
And what about hyperthermia, it in one form or another has already been widely and successfully used against cancer, AIDS and other diseases (In Russia, this is Moscow, Novosibirsk, Nizhny Novgorod). A little offended that I suggested the use of hyperthermia against cancer and AIDS long before it drew up their proposals all subsequent "authors". I am only limited by the fact that I registered my ideas at a notary office and sent letters into four Academies of Sciences.
Why do I have not patented my ideas a timely manner? Because:
- my work is not related to medicine,
- I have no medical education,
- medicine (and law) is an area in which in most developed countries nobody is allowed to work without a suitable diploma,
- for being too "revolutionary" ideas here in Russia people are often placed into a madhouse, that did not fit into my plans.
And now I move to the more interesting question.
Around 1980 I was working on a challenging theoretical problem, and gradually entered into a state of merging with the Absolute, Absolute Knowledge, or "Samadhi" (this is what I later learned from books on yoga). I was in this state, about month and a half, but the memories of this will be enough for a lifetime.
As a result of "Absolute Knowledge" I opened the knowledge of the interconnectedness of all things in nature, after that I decided to formulate the most important law of nature - Law of World Harmony (as I called it). However, I made this only eight years later - in May 1989. After that I wanted to use my universal law in anyone important area for people. Many media then reported that the main enemy of mankind is AIDS.
I found a good article on this subject, reviewed all internal and external manifestations of AIDS, and then, based on my Law of World Harmony, proposed means of its treatment.
Many years passed since that, but I have no doubt in my truth. As I wrote above, hyperthermia is already used to treat AIDS, cancer and many other diseases.
P.S. Your website (www.geocities.com/pharmharm) I've looked but I can not say anything because I am very far from the pharmacy.
hello,After such a letter, from which wafted "militant infallibility" Michael Leitner representations about the nature of AIDS, I felt very uncomfortable. However, I "took a deep breath" and answered him by the following letter.
I am sorry to tell you, that I am not interested in you therapy. I have been reading nearly the whole article, but to me, your attempt can never bring benefits to patients because of a few simple reasons:
1. "HIV" is not a virus, but a laboratory artefact, brought to market by scientific thief Robert Gallo; who has stolen some ideas in producing the lab.artefact from Luc Montagnier
2. Every isolation of "HIV" doesn't fullfill one simgle rule for classic virus-isolation.
3. Every available statistic and epidemiological data deny the existence of AIDS as an infectious disease (just like BSE, hepatitis)
4. The HIV-antibody tests have cross reactions to 70 known factors, that have nothing to do with "HIV"
5. The PCR ("viral load") multiplies any DNA of every cell fragement, contained in blood
In absence of an infectious agent, but in presence of an intoxification disease, it makes absolutely no sense to heat a patients blood. The only effect is destroying some DNA-structures of cell fragments, what of course can lower the "viral load", measured by PCR (HV RNA). But this can never be a suitable treatment for all 30 diseases, that have been sumariesed under the construction of "AIDS".
more information: www.aids-info.net , a primary german website
much more information in english: www.virusmyth.com
Hello, Michael!Soon from Leitner came a second letter:
I am very grateful to you for your interesting letter, but in my text you have understood the term "HIV" too literally. I used the term "HIV" 14 years ago, meaning by it only "cause of AIDS." HIV in material form simply does not exist (in which our views are close).
As for the "benefit to patients," then I ask you to open the following English references, where these benefits are described in explicit form:
Thus, the effectiveness of my proposals is now widely demonstrated! The fact: AIDS is "noncommunicable" desease is already well represented in my articles (here we are close again!).
However, the absence of an infectious agent, does not show the senselessness of my hyperthermia. My hyperthermia did not kill anyone, it only leads to a breakdown in communication (sticking) between the two T-helpers (see my chart in the article Diseases of "Chain Reaction-type"). Thus, freed of T-helper cells can continue their "good work"!
I am very grateful to you for your opinion!
If you want to write me, I am waiting for your response.
Sincerely, Sergey Makarov (firstname.lastname@example.org)
Hello Sergey!My answer to the German journalist Michael Leitner was the ARTICLE FOUR, which was called "On the theory of AIDS". Namely with this article I decided to finish a series of my publications on the topic of AIDS at "Kurierweb.com" in spring of 2003.
your first link www.medicalcenter.narod.ru/english/index/html doesn't work! 404 No such page
the others contain no information concerning "HIV/AIDS"!
And according to available data, patients treated with chemotherapy have a life expectacy much smaller than patients NOT TREATED ANYWAY. (3,5 years with chemo, 12 without).
The cancer mafia ist nearly the same, the AIDS-mafia is. All AIDS-researchers in the early 80ies have been (unsucessfully) researching retrovirusses as the cause of cancer. And both developped therapies, that kills patients faster than refusing any therapy.
Because I am writing a new book on the Bush-Iraq-conspiracy, I don't have the time to read scientific texts, especially when written in english. In addition to your information, I would have to read texts, explaining the theory, your therapy is based upon.
The attached file comes from an engeneer from eastern Germany. This, to me, represents an excellent way of documenting a new treatment. In our world, people do need pictorial evidence!
His treatment REPLACES chemotherapy and radiation; it should be used in addition to long-term nutritive measures.
The theory is based upon the cancer research of Otto von Warburg (nobem price in 1929). Warburg has found some interesting facts on the metabolism of cancer cells and he has realized, that cancer cells do have an inverted electric character, compared with regular cells. His electro-magnetic therapy acts locally, and it is based upon the actual research of a chinese doctor.
If you want to cantact Hans-Peter Bartos: Hansemail@example.com . Maybe you can change some ideas... . I don't know, if Bartos can read + write english well. Because everyone in former Eastern Germany was condemned ;-))) to learn russian, there's a chance that he speaks your mother-language better than english.
Hello, Higa!Higa to Sergey (March 19, 2003):
All my texts are accessible in English, see the references at the center of this page:
I am very glad to meet a friend, which likes Pushkin!
Sincerely Yours, Sergey.
Ola, Sergey,My response (March 19, 2003):
We visited the site you indicate, but found no one English translation! Just an enormous confusion of images...
Hello, Higa!Higa to Sergey (March 19, 2003):
I don't know the reason of that, so I send you my english papers... (vivod_en.doc, chain_en.doc, aids_en.doc)
Thank you very much for your very interesting papers which I could now read!!!My response (March 24, 2003):
Hello, Higa!Higa to Sergey (March 25, 2003):
My third article was printed yesterday ("About AIDS theory"). You would like to read it, I think. I send it to you!
What do you think about the previous articles?
Dear Sergey,My response (March 25, 2003):
Reading your articles I got the impression, that you still want to fight some kind of AIDS virus, which in my opinion does not exist.
The heat therapy is confirmed to be very effective on several occasions, but we believe that (AIDS being an immune deficiency caused basicaly by toxemia) the most important treatments view the desintoxication of the organism.
For us all medical therapies are just crutches!!!
Thank you for your help and a big hug from Higa.
Hello, Higa!Higa to Sergey (March 26, 2003):
I got your letter, thank you very much!
But your letter very surprised me. "...the HIV term should be buried,"- I wrote at the end of the third article, but you consider: "He wants to fight the virus..." (?!)
Why in Novosibirsk the hyperthermia shows very high efficiency against AIDS, if the AIDS (in your mind!) is a toxaemia? In this case (toxaemia + hyperthermia) such a therapy should move a man to the coffin, I think. But results are absolutely reverse.
May be your AIDS-schema is wrong?
Sincerely Your's, Sergey.
Dear Sergey,My comment: I'm so aggressively "dig" under the true "basis of faith of rethinkers" (I mean Leitner & Higa as "true rethinkers"), that they, in my opinion, are themselves already doubted their previous beliefs.
It is very difficult to discuss such a complex issue by e-mail. That AIDS is mostly a toxemia is not in my head but in all the vast dissident literature you can find on our website.
"AIDS" is such an umbrella term that in many cases the patient may benefit from thermal therapy.
Best wishes for you and your patients
SERGEY, GOOD DAY!My response (April 14, 2003):
I read your article about AIDS and cancer. Your article became very interested to me. Few will tell you about myself. I live in Israel, now in its seventh year. By education I am an electronics engineer. Now, though, I do not work in my specialty.
A science and industry is not worth in place. Every day is something new and for this to be looked after. But it's not the main point.
The fact that my wife is sick with cancer. Now she gets a second course of chemotherapy. She is very unwell. Now I looked at a lot of information in the Internet on Cancer and your article, I also found in the technical library.
I would like to ask you. Since the registration at a notary passed 14 years. In addition to the article you were doing some experiments? Or maybe, the industry already produces such a setup?
I'll cling to any thread, to help my wife. In Israel, are developed many kinds of industries. Maybe we could have together to do something. What do you think about what I wrote to you? If you can reply to my letter to you I'll be very grateful.
Yours! Vyacheslav Azyassky.
Hello, Vyacheslav!(Retrieved from Vyacheslav Azyassky (firstname.lastname@example.org) April 25, 2003)
It was nice to get your letter in a purely Russian, since I already "tired of English".I'll try to answer all your questions.
October 27, 1989 I signed a contract with one firm to develop and apply the proposed method, I treat AIDS and cancer diseases. June 27, 1990 I was told to break the contract, because "in view of the secrecy of information about cancer and AIDS treatments, the firm has no opportunity to conduct a patent search," without which the development of this theme does not has any sense.
In September 1991 I tried to bring to the subject the Soviet-American Medical Enterprise "Svelen" in St. Petersburg. After some delay I was told that all my suggestions have already been patented in Philadelphia (USA), while specific materials have not shown me. Many years later I realized that it was a lie: the head of "Svelen", apparently, just wanted to steal my suggestions, but it is probably not work.
In short: with my participation in 14 years no development has been done. I paused at 13.5 years, in order to "enable humanity to think things through, and became a little smarter." It turned out that in recent years, some people have gone down this path and obtained encouraging results.
Since the "lyrics" you hardly care, I give you specific addresses:
http://www.medicalcenter.narod.ru/frame/method.html – International Health Center in Novosibirsk (Russia),
http://nt22.by.ru/info/index_t.html – International Academy of new medical technologies in Russia,
http://www.innov.ru/yug/publik.htm – firm "Mera", Nizhny Novgorod (Russia).
Personally, I am with none of them did not speak, but according to my data in the direction of hyperthermia against cancer, they have advanced far enough. I myself at this time is unlikely your wife will be useful here, I have not gone far than pure theory. My participation in the process of developing a method I suggested for many people, even Bill Gates, who in January of this year "threw" 200 million USD «to address the global problems of mankind", the first of which is called AIDS.
The most interesting thing that the foundation, which was created by Bill Gates is not going to treat anybody specifically (!?), and will be engaged primarily in prevention.
I hope my links can help you. Tell me how old you are, where are you working, what movements and what news comes to you in this matter.
In my database there is no trace that I sent you a letter. Could you tell me what sources you know about me.
I have published only three articles. If you have not read all of them, look: www.kurierweb.com/publications . After opening this link takes a little to scroll up and find all three articles.
Yours! Sergey Makarov (email@example.com)
April 14, 2003
Sergey, good day!My response (April 27, 2003):
Sorry for the delay in replying. My wife is now in the hospital and so I was not up to the Internet. Every night I was on duty at the hospital.
I am grateful for the information which I received at the letter and fo the links to some sites. I do not know how much all true, for example, in Novosibirsk, but what they do is, of course, great.
How to become a little easier, I want to send them all the tests, can they have something to prompt. To you I came from an article that I got from subscription.
Here it is: "Physiotherapeutic methods of treatment of AIDS and cancers"
© Sergey Makarov
Contact author: firstname.lastname@example.org
Publication Date: March 12, 2003
A little about myself. I am 51 years old. I work in munitsipaletete. We in Israel about the method of hyperthermia not been heard from. I first learned about it from your article. If I have something else I find out I'll write to you.
Once again, thank you very much.
Sincerely. Vyacheslav. If not a secret where you live?
I hope that my participation was helpful and your wife will receive the necessary assistance.
I am 52 years old, I work in the field of information technology (computer accounting), I live in the city of Gatchina, Leningrad region
I was pleasantly surprised to learn that you have received RUSSIAN text of my article by the subscription in Israel. The fact is that in SciTecLibrary.com there is an English version, but the basic "information holder" who has published three of my article, this: www.kurierweb.com/publications. If you go to this address, go a bit down the page, there you will find THREE of my articles on this subject (both in Russian and in English), one of the articles you read. I think that you'll like my other articles too.
Two days later I am going to move to Riga (Latvia), my "communication parameters" will get some changes. If you decide to write, it is better to write to the address: email@example.com.
Sincerely and with best wishes!
To Virna Medina (firstname.lastname@example.org), Jakarta, IndonesiaReply from Indonesia by Virna Medina (email@example.com) March 27, 2003:
I am a Russian engineer, who is not indifferent to the problems of mankind.
Some years earlier I tackled the problem of AIDS and, basically, I decided it. Information about my method of physiotherapy treatment of AIDS, as well as my article "Diseases such as "Chain Reaction" and "On the theory of AIDS" (in Russian and English) can be found at the link:
It's a whole new perspective on a well-known problem. Recent studies conducted in Novosibirsk (Russia), Nizhniy Novgorod (Russia), fully confirmed my theoretical conclusions!
I hope you can appreciate my ideas, that you inform them of their colleagues, and then let me know your opinion regarding this issue.
Sergey Makarov (firstname.lastname@example.org)
Thank you for sending me this information, it's very kind of you. I try to access to your website and succeed but actually I don't speak and read russian language :-)My comment: I do not know why she did not want to sign her letter, but, nevertheless, 29 March 2003 I sent her an e-mail and attachment with all my four articles in English. This my letter is not preserved in my archives and I never got the response to it (probably due to my moving to Latvia).
So... it'll be very convenient for me if you care to send me the soft copy in English or maybe you have another website in English ... don you mind informing me later on?
Thank you again and keep on fighting. I know I am.
By the way ......... yesterday I walk passed a campus in Jakarta, Indonesia and I accidentally read the banner hanged there. Its daid : This campus is drugs and AIDS free territory. I was so sad reading that ,.......... I'm also very angry but I don't blame them for saying that because they don't know much about AIDS.
Hello, Alexander!My explanation: after I sent my packages, the popular journalist Alexander Khabarov "stalled like a machine gun" from one throw a bunch of grenades Alexander Matrosov. More he did not show any activity, although, thanks through notices, I know that he had get all my "packages".
I guess I'm a bit older than you, and therefore decided to contact you so "familiar".
In your speech on television I was "touched" your call for help in the fight against AIDS and, specifically, your phrase: "Knowledge, ability and desire to protect..."
I dare say that the topic of AIDS as well as many other "so strong topics" is used by so many "experts" for "invention" their dissertations, procurement of disposable syringes, etc., and, ultimately - to launder and "production" of money. In this regard, almost none of the "powers that be" simply is not needed the real solution to this problem.
If you believe that this is just my "emotions", it's not right. I know whereof I speak. I think that the attached to my letter documents will convince you on this question.
Because the documents are voluminous, I am sending them one by one in three e-mails, as your communication channel, apparently weaker than my (I have high-speed cable connection with a full Internet Service).
My "Physiotherapeutic method AIDS cure," I suggested to many organizations, including the Academy of Medical Sciences of the USSR (05/23/1989), Scientific Secretary of the Academy of Sciences of the USSR(05/23/1989), Latvian Academy of Sciences (05/23/1989), medical center "Svelen" (September, 1991.), Magazine "Zdorovje" ("Health") (05/23/1989), the center "Basis" in Gatchina (10/27/1989), and others - all to no avail.
So I "paused" about 12 years (I hoped: humanity will be smarter!). And then I saw your program, from which I learned that "things are there". Your may try to move question from its place. But keep in mind that what I sent to you is, in my view, "time bomb" and in a good scenario, you will gain "weight" and journalistic popularity, and in bad - a lethal outcome (for both of us).
So, I am sending your three letters with attachments!
The first attachment – metod.zip
Good luck! My e-mail: email@example.com
Subject: To Alexander Khabarov about AIDS_2
Package number two on AIDS (rahman.zip).
Gatchina, Sergey Makarov.
Subject: To Alexander Khabarov about AIDS_3
I send my third pack on AIDS (svel_baz.zip). Just in case, I inform you: "Svelen" hasn't sent me a copy of the patent, which he opposes to me. It seems that "Svelen" simply disappeared...
Gatchina, Sergey Makarov.
Hi, Sergey!Reply from Sergey Makarov (firstname.lastname@example.org) to the International Health Center (email@example.com)
I resend this message to you and wish you success!
----- Original Message -----
From: "International Health Center" (firstname.lastname@example.org)
Sent: Friday, March 07, 2003 3:00 AM
We are very interested in S.G. Markov's articles (My comment: actually, my name is "Makarov")
"Cancer and AIDS can be defeated by means of "black box" manner?" and "Diseases of "Chain Reaction-type"", have been published on your website.
We kindly ask the author to contact us in terms of possible cooperation.
Sincerely, R.I. Chervov, doctor of the autonomous non-profit organization "International Health Center"
phone: (3832)182270, fax: (3832)182100
mailto: email@example.com, website: http://www.medicalcenter.narod.ru
Hello, dear Chervov R.I.!After the letter from me R.I. Chervov, he simply "stalled like a machine gun" from one throw a bunch of grenades Alexander Matrosov. If he had something explained to me, I would have probably realized him, but he (comrade Chervov R.I.) was not the "scientific man" but a "simple Soviet man."
"Kurerveb" informed me about your and the Medical Health Center's interests to my published information. I am willing to consider your specific proposals.
Write to me at my personal E-mail-address posted below.
Yours! Sergey Makarov.
From Alexey Berkovsky (firstname.lastname@example.org) Sergey Makarov(email@example.com)My answer on February 19, 2003
Date: February 15, 2003
Good afternoon, Sergey!
Thank you for your message. A few weeks ago I have got acquainted with your article, but I can not get together with the answer.
Unfortunately, I can not place your article in the form in which it is published on the website www.kurierweb.com. The reason is that, in agreement with www.aids.ru I have no right to publish material about "unconfirmed" treatments. Please understand me correctly, here I am in a "servitude", as though it might sound strange, but unfortunately, it's so...
However, if your article would have less "promotional" in nature, ie will be filed in the style of "review" (as an alternative method of treatment), then I think that I can to publish it without violating the agreement.
I totally agree with you in looking at specialized institutions of our great planet (...too few people can in the name of truth "cut off a branch on which it sits"). I myself have been watching the same picture in the theme of HIV/AIDS for the fourth year.
This issue, regrettably, has become a real business - donors had divide all "market" and grants are given not by competition (formality), and "by the list". There is a pure "money laundering" and zero results in HIV prevention. Pharmaceutical companies do not need your treatment. If you are right, then where do they do with their medications and how they will be able to return invested in their development funds? Sad, is not it?
Please forgive me if I disappoint you this letter. Alas, the situation is namely so (in any case, I haven't doubts about it).
Sincerely, Alexey Berkovsky, "AIDS infosite" administrator.
"AIDS infosite" - an information resource on HIV/AIDS.
Phone: (057) 772-01-84, Alexey
E-Mail: firstname.lastname@example.org, email@example.com, WWW : www.infosite.aids.ru
Hello, dear Alexey Berkovsky!AIDS is not sleeping!
Thank you for your wonderful letter. Perfect in the sense of openness and clarity, but the history will judge the rest of it.
As you hinted, I can write, and you publish the "good article about AIDS." I did so (see attached text - ne_spit.doc). My paper is so innocent as "Penitent Mary Magdalene". I hope to publish this article in your journal. I think that your readers will be satisfied.
I am waiting for your decision!
Segrey Makarov (firstname.lastname@example.org)
«But let your words be simply, Yes or No: and whatever is more than these is of the Evil One».
(The New Testament, Matthew, Chapter 5, Verse 37)
When I proposed the method of physical therapy for AIDS, I sent the results of over 500 professionals around the world. Most of them, apparently, "just laughed" at me and threw my letter into the trash". However, among physicians there are also serious people with an open mind and open heart.
Dr. John Kirkham (email@example.com) from Great Britain, in his letter to me wrote verbatim:
«...your theory, I think, involves a consideration of the fundamental physical processes instead of exotic viral device, it is calling for a fundamental approach, with what namely begins true scientific method, something THAT PREVIOUSLY NEVER HAD BEEN AMONG HIV-HYPOTHESES».
In Russia, in such cases we say "hit the bull's-eye." It is my deep conviction, where "fundamental review do not engage in a process", there is no science, but only pseudoscientific twaddle. I forced to admit: that letter from John Kirkham inspired me to this article, which I think will be the fifth and last of my articles on this topic because I am already very tired of this topic.
I feel that this article in the medical circles cause shock in someone, but someone will be highly offended from it. However, nothing can be done. At the entrance to my site is written the motto: "Do what you have and whether it would be!" When I do something "should" (which is always known only to God), I just can not sleep – Someone is doing my moving out of bed till my desk. That's what happened today.
I just say: I am a follower of the Kozma Prutkov method and this method is formulated as follows: "Find the beginning of all things and you will understand much!" Therefore, I DO NOT CARE WHO BEGINS THE HARMFUL CHAIN REACTION INTO THE HUMANS BODY.
Doctors and biologists love to juggle with the words: HIV, AIDS, hydrocephalus, lupus, smallpox, cancer, blood poisoning, etc. But a serious shaman will not "juggle terms" and to join with someone in a "pseudo-debate." He is simply "from a sick man will make a healthy man". And this is what all normal people expect from a good doctor.
For those who experienced "intuitive distrust" from shamanism, I want to give the result of observation of shamanic therapy and pharmacology of anthropologist Jeremy Narbi, who has studied the healing practices of shamans in the Amazon during 10 years:
"Warlocks of autochthonous tribes of Amazonia - the very good therapists, they have a deep knowledge of pharmacological and never wrong". (See "Shamans are seeing the DNA of plants and animals" from the № 1 book "NEXUS in Russian" for 2008)
Here it means to be a "healer of God" (or "healer of Nature" - as you like). No any such medical diploma, which will be able to help a person of modern civilization to approach this perfection.
We turn now to the "modern medical science." The U.S. government allocated huge money for the AIDS program. In this case, only those funded by medical developments which are based on the only official version of the cause of AIDS. All other versions are not funded and are simply ignored (as though they simply did not exist). However, there is every reason to believe that an official human treatment from AIDS (for example, using AZT and other chemicals) only accelerates the "relocation of people into the coffin."
Some people suspect me of bias, and ask: "How do we know that without chemotherapy, patients could live longer?" Yes it is known from the experience. This has already been taken care of AIDS-dissidents: there are many facts from dissidents that certainly proved: AIDS patients without treatment are able to survive several times longer than in the case they "were strong cured" by therapists (see, for example, a second letter from the German AIDS-dissident Leitner).
If someone else wants to talk about "the benefits of modern Civilized medicine", then I will give the following interesting quotation:
"Statistics show that as soon as doctors anywhere on strike, mortality in this region is markedly reduced. In 1976, during the mass strikes of doctors mortality in the Colombian capital of Bogota, has fallen by 35% and in Los Angeles by 18%. In Israel in 1973 during a strike of doctors mortality decreased by 50%. Such low mortality was observed in Israel only once, twenty years earlier, and also during the strike of doctors. At the end of the strike mortality returned to its previous level." (see the biochemist and toxicologist Walter Lasta article "Medicine is healthy, as long as we are sick?" from the № 1 book "NEXUS in Russian" for 2008)
Comments, I think, unnecessary.
On this topic I want to give you a contemporary anecdote.
The patient needs care physician. And the lesser will be this care, the healthy will be the patient.
Honestly: if I were a doctor (luckily, "God spared me"), I would now doesn't show my profession in public (this does not apply to the honest doctors). For no honest doctor I have another question: "Do you feel yourself well, if you get from sponsors two trips for the rest during a year for what you write patient only those drugs that a sponsor has decreed that you must write?" Or you not defame in this case your diploma and your "Hippocratic Oath"? Questions, as they say, "rhetorical". I honestly do not hope to hear the answers to them (just among doctors, are already "sold his soul to the devil", daring is not a single).
Maybe someone from the doctors was offended by me because of the mentioned above reproach in the "sale of soul to the devil". Someone might even think that this accusation is far from real life... To this occasion I can only provide a link to the article (in Russian)
"TV3: doctors have sold themselves to pharmaceutical company for candy, whiskey, and travels"
from portal http://rus.delfi.lv/. In this article was directly written that there is evidence of illegal relationships between doctors and drug manufacturer. So in the mentioned above reproach to doctors I did not invent anything.
My "Lyrical digression": once upon a time I worked in the design department of one Design Institute. During a serious dispute with my head of department at designing a unique construction, I dropped such a phrase: "Yes, I just feel how each building element works under load!" At that he laughed at me and said: "Well, well ... no one feels, and he, you see, feel ..." "What can I do if so? - I said. Soon I had to leave this institute.
You can consider me a "modern shaman", but I just have to tell you this words: all these medical terms to me, by and large, are not interesting. Look at my scheme of PID and HIV. This is the "essence". God is conceived to situate T-helper cells into the human body on guard on the input of infections.
If someone these defenders has "tied and threw out", the body became weakened. And if the body is left without the protection provided by God, any infection can "bring him to the grave" (well, little amount of T-helper cells remains, thymus gland can not produce them at enough quantity). To this "fact" can join hundreds of "collaborators and competitors," "wrap up" all this with pseudo-scientific terminology and to make of this fact thousands doctoral dissertations - that's not my question.
Do doctors for some reason they consider normal to make small steps in the direction of the fight against AIDS, cancer and get for these small steps great Nobel Prizes. Excuse me, gentlemen, if I became an obstacle on this way.
I want to write the following for serious people: if a person suffers from diarrhea, the reasons for this may be only two: either the organism itself by means of its T-helper cells is struggling with some input infections, or its T-helpers "are attacked" by some parasitic chain reactions, which is "ties them and throw out from the body." Third path not exists. In both cases it is bad and deserves to be challenged. On this field many doctors can do a lot of dissertations too (separate disease - a separate dissertation), but it's not my question too.
One of the «rethinkers» wrote to me that AIDS doesn't exist, but there is blood poisoning, which is called AIDS, another wrote that the term "AIDS" unites about 30 viral processes in the body, the third wrote that the term "HIV" I am not correct understanding...
I'm not going engage in debate with them, because in this direction I had already "found a start point" and pointed out how to fix the situation - people, take it, please.
For those physicians who still authoritatively declare: "AIDS is not exist", I'm ready to play with words for the last time. It is not so difficult to me.
I think that everyone knows the concept of "deficiency". This is a shortage of something what you need. "Immune deficiency" - I think everyone will understand that this is "lack of immunity" or "lack of defenses" in a certain organism. "Acquired immune deficiency" means that you didn't posses this "shortage" at birth, but you somehow got it in the process of life. "Syndrome" - is, in general, "a set of detectable characteristics" (see Wikipedia), roughly speaking it is "a set of indicators" or simply "an indicator".
Thus, we make up the phrase: "Acquired Immune Deficiency Syndrome" (abbreviated: AIDS). Someone can deny the fact that so many diseases lead people to diarrhea? Nobody can deny it. With diarrhea protective forces have been lost? Have been lost.
Who still believes that AIDS is not exists, let "throw the first stone at me". I think that such a person is something "wrong with his logic" or simply "his head is ill". Such people may try to talk about what namely "in their group of like-minded" is considered to be AIDS. However, this is not interesting.
Mankind has invented the term "AIDS" and I just detail re-wrote (just recalled) all the sense that this word (this abbreviation) containes. Perhaps this is the most "decent" word in medicine in the sense that most ordinary people can understand, from what words this abbreviation is formed.
February 18, 2003 I sent an email to Berkeley in the clinic of Professor Duesberg, who is actually the head of the global community of AIDS dissidents ("rethinkers"). I was hoping that my letter brings him some pleasure (I "poured water on his mill") and he'll finds the time, "drop me some words ..." It's a shame that he has not answer a word to me. Now I have to admit that all of my above-described "playing with words" is most relevant to the distinguished Professor Duesberg.
And now read the opinion of one participant internet forum regarding hyperthermia:
Frequent participant in the forum
Mr Luzevich A.N.
Periodically again arises theme of hyperthermia in the fight against HIV. And periodically, I send my answer to developers and advertisers following remark: how you can "mold the hunchback to the wall"?
Now specifically about the hyperthermia. I do not know how the thermal shock will impact on the state of the receptor's part of the immune complex, sure that the authors of this method have not investigated this point. A change in the encoding receptors CD-4 could lead to shut down the immune system with all its consequences. This is just one little touch to the procedure. It can be also specified that the thermal effect on the HIV virus will lead to higher levels of replicative activity of virions forming syncytia, what, in turn, will accelerate the transition to the stage of AIDS. In addition, hyperthermia can lead to a sustainable increase tension in the process of anaerobic oxidation of monocyte-derived cells at early stages of infection with a simultaneous decrease in the intensity of threecarbon acids cycle, which, in turn, leads to permanent reduction in the activity of succinate dehydrogenase and lactate dehydrogenase as a factor in the oppression of the functional activity of monocytes.
Activation of the pentose cycle and increased the decay of purine bases lead to the activation of prooxidant NAD-systems, that will not be compensated by increased function of antioxidant systems (superoxide dismutase, glutathione) and trigger increased activity of trypsin-like endonucleases with the development of degradation of nuclear chromatin. All this will lead to imbalance of monocytes and their premature death. When will you all understand this?
Source (in Russian): http://www.sciteclibrary.ru/cgi-bin/yabb2/YaBB.pl?num=1047540543/110#114
The shown above excerpt I presented without any exceptions or additions. When at forum I read it in the original, I for some reason felt very sad. I thought: what is appropriate in a scientific dissertation, it is absolutely not acceptable, for example, on an Internet forum. If a person does not understand this - God will judge him. Apparently, he was so confident in his professional infallibility that he decided to "sing of her as a grouse on a lek".
I could spend time on it, to defeat the above professional opinion regarding the impact of hyperthermia on the human body. But after my first indignation went away, for some reason I absolutely didn't want to do it.
I just want to remind him and the other readers of Einstein's point of view on this topic. He argued that a new scientific theory is good only then, when "the essence of this theory, you are able to explain to the first comer on the street..."
After the opinion of a professional, which was shown above, in my soul arised the opinion: I would have never go for the treatment to such a professional. It seems to me that he loves himself and hates the people around him.
Of the four articles once published by the website "Kurierweb.com" the third one was called Diseases of "Chain Reaction-type". I had everything laid out enough clearly, even suggested to open a new direction in medicine (which coincides with the article's title). I WAS NOT HEARED. After that, I want to say one thing: juggling, gentlemen, please, your medical terms, earn good money on this. I will no longer mate to you.
February 03, 2011
February 10, 2011
«Give me a chance to create a fever and I will cure any disease.»
Parmenides, a Greek physician and philosopher (540-480 BC)
|Number, Date, Author(s), Article Title
Crile G., Jr.
SELECTIVE DESTRUCTION OF CANCERS AFTER EXPOSURE TO HEAT
|Experiments in mice, dogs, and humans show that heat selectively damages tumor cells and makes them more sensitive to ionizing radiation. Observations on the effect of heat and radiation on three types of transplantable tumors in mice show that the destructive effects of heat begin at 42 deg C, at which temperature it takes several hours to damage tissues. For each degree that the temperature rises above 42 deg C, the time of exposure required to obtain the same biologic effect can be halved so that exposure of less than a minute at 49 deg is equivalent to 2 hr at 42 deg . The tumors were transplanted to the hind feet of mice and were heated in a constant-temperature bath. The tumors showed a spectrum of heat sensitivity that correlated closely with the radiosensitivity of the same kind of tumors. The effects of radiation on even the most radioresistant tumors as well as on normal tissues was greatly increased when the tissues were heated just before or just after the radiation was given. Although heat-resistant cancers that are heated to 44 deg C for 30 min. before they are irradiated can be destroyed by less than half the dose of radiation that is normally required, heating induces a similar potentiation of the radiation effect on normal tissues. It is thus difficult to be sure that radiation combined with heat is any more effective than a larger dose of radiation would be if given alone. However, some radioresistant tumors, such as the T241 sarcoma implanted on the feet of C57BL6 mice, can be controlled by heat and radiation without damage to the foot, whereas larger doses of radiation alone usually fail to cure, or in doing so damage the normal tissues. A higher proportion of mice with S9l melanoma also can be cured by combining radiation and heat than by employing either treatment alone. It was also established that there are tumors in dogs and man that can be selectively destroyed by heat without damage to the surrounding tissues, but these heat-sensitive tumors are rare, and unless they are superficially located there is as yet no safe way to apply the heat.
|Ann Surg. , 156(3): 404–407
|СЕЛЕКТИВНОЕ РАЗРУШЕНИЕ РАКА ПОСЛЕ ВОЗДЕЙСТВИЯ ТЕПЛА
|Эксперименты на мышах, собаках, и людях показывают, что нагревание выборочно повреждает опухолевые клетки и делает их более чувствительными к ионизирующим излучением. Наблюдения о воздействии высокой температуры и радиации на три вида опухолей у мышей показывают, что разрушительное воздействие тепла начинается при температуре 42 ° С, при этой температуре оно занимает несколько часов до повреждения тканей. Для каждой ступени, когда температура поднимается выше 42 ° С, время экспозиции, необходимое для получения того же эффекта может быть снижено, так что воздействие менее чем 1 минута при 49 градусах эквивалентна 2 ч при 42 град. Опухоли были пересажены на задние лапы мышей и нагревались в ванне при постоянной температуре. Опухоли показали такой спектр чувствительности, что нагревание коррелировало в тесном сотрудничестве с радиочувствительностью опухоли. Воздействия радиации на самые радиорезистентные опухоли, а также на нормальные ткани значительно возрастали, когда ткани нагревались до или сразу после облучения. Жароустойчивые раковые образования, которые нагревались до 44 ° С в течение 30 мин., прежде чем они будут подвергнуты облучению, могут быть уничтожены менее чем половиной дозы радиации, которая обычно требуется; нагрев вызывает аналогичные потенцирование радиационного воздействия и на нормальные ткани. Таким образом, трудно быть уверенным, что излучение в сочетании с нагреванием оказывается более эффективным, чем просто большие дозы радиации, которые быти бы даны в одиночку. Однако, некоторыми радиорезистентными опухолями, такими как саркома T241, имплантированными на ногах C57BL6 мышей, можно управлять с помощью нагрева и излучения без ущерба для ног, в то время как большие дозы радиации наносят ущерб нормальной ткани. Высокое число мышей с меланомой S9l также может быть вылечено путем объединения радиации и нагрева, чем при использовании их отдельно. Также установлено, что у собак и человека есть опухоли, которые могут быть выборочно уничтожены нагреванием без повреждения окружающих тканей, но эти термочувствительные опухоли встречаются редко, и если они не расположенны поверхностно, то пока еще нет безопасных способов применения к ним тепла.
HYPERTHERMIA IN THE TREATMENT OF CANCER
|There is now considerable evidence that heat can be used to destroy tumours. The metabolism of many types of cancer cell is selectively damaged at temperatures of 42-43°C, and deficient tumour blood-flow at raised temperature represents a further exploitable Achilles heel. A striking feature of tumour heating is that metastases may regress with cure of the host; this has occurred with recurrent melanoma and sarcomas of the limbs. Heat acts synergistically with X-rays and some cytotoxic drugs to increase the therapeutic ratio for local tumour control. Guidelines for tumour heating are now being formulated against a strong experimental background in animal systems. The association of a wide variety of disciplines from oncology to electronics has already resulted in techniques for selectively treating human tumours at 50°C and in internal heat applicators for insertion via natural passages. It is predicted that heat will achieve a place, most likely as an adjuvant, in cancer therapy. Work on animals and in vitro is of limited value in helping to define this place. The complexity of the tumour/host response to heat and the deficiencies in our knowledge of the biophysics of heating militate against early routine application of hyperthermia in the clinic.
|The Lancet, Vol. 313 No. 8109 pp 202-205
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА
|В настоящее время имеются достаточные доказательства того, что тепло может быть использовано для уничтожения опухоли. Метаболизм многих видов раковых клеток избирательно повреждается при температуре 42-43 ° С и дефицит кровотока в опухоли при повышенной температуре представляется ее дальнейшей ахиллесовой пятой. Поразительная особенностью нагревания опухоли является то, что при лечении хозяина метастазы могут регрессировать; это произошло с рецидивной меланомой и саркомой конечностей. Тепло действует совместно с Х-лучами и некоторыми цитотоксическими препаратами для увеличения терапевтического соотношения при местнои контроле опухоли. В настоящее время разрабатываются руководящие принципы для проведения нагрева опухоли против сильного фона в экспериментах над животными системами. Объединение самых разных дисциплин, от онкологии до электроники уже привело к методам выборочного лечения поверхностных опухолей человека при 50 ° С, а также во внутренних зонах с помощью вставки аппликаторов тепла в природные проходы. Прогнозируется, что тепло будет применяться, скорее всего, как вспомогательное средство в терапии рака. Работа на животных и в пробирке имеет ограниченную ценность, кторая помогает это определить. Сложность анализа ответа опухоли на нагревание и недостатки в наших знаниях о биофизике нагрева препятствуют скорому применению гипертермии в клинической практике.
STATE OF THE ART AND PROSPECTS ON THE USE OF RADIOFRE- QUENCY AND MICROWAVE HYPERTHERMIA IN CANCER TREATMENT
|The use of microwave hyperthermia for cancer treatment is dealt with, first analyzing the present state of the art, second from a prospective viewpoint. Follow current topics are considered: a) biological data from experiments in vitro and of animals; b) fundamental therapeutic modalities: total body hyperthermia, local hyperthermia; c) technological problems: irradiation frequency, applicators, dosimetry (non-interfering probes, microwave radiometers); d) results of preliminary clinical investigations. Prospects refer to following topics: a) technological: improvement or design of systems for producing and controlling hyperthermia; b) fundamental: models, phantoms and postoperative specimens; dielectric and thermal properties on tissues; part of the vascularization; c) clinical: treatment procedures, long-term therapeutic trials (exclusive or combined hyperthermia, cancerous and healthy tissues).
|J Radiol, Vol. 60 No. 11 pp 685-9
|СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РАДИОЧАСТОТ- НОЙ И МИКРОВОЛ- НОВОЙ ГИПЕРТЕРМИИ В ЛЕЧЕНИИ РАКА
|В вопросе применения микроволновой гипертермии для лечения онкологических заболеваний, рассматривается, во-первых, оценка современного состояния вопроса, во-вторых, его перспективы. Рассматриваются следующие актуальные темы: а) биологические данные экспериментов в пробирке и на животных; б) фундаментальные терапевтические методики: общая гипертермия тела, местная гипертермия; в) технологические задачи: частоты облучения, аппликаторы, дозиметрия (без вмешательства зондов, радиометры СВЧ); г) результаты предварительных клинических исследований. Перспективы относятся к следующим темам: а) технологические: улучшения или разработка систем для проведения и контроля гипертермии; б) фундаментальные: модели, методы и послеоперационные результаты; диэлектрические и тепловые свойства тканей, процессы васкуляризации; в) клинические: лечебные процедуры, долгосрочные клинические испытания (без или в сочетании воздействия гипертермии на раковые и здоровые ткани).
S Ostrow, D Van Echo, M Whitacre, J Aisner, R Simon, P H Wiernik
PHYSIOLOGIC RESPONSE AND TOXITY IN PATIENTS UNDERGOING WHOLE-BODY HYPERTHERMIA FOR THE TREATMENT OF CANCER
|Seven patients with advanced cancer underwent whole-body hyperthermia using a nylon and vinyl mesh, water-perfused suit. Treatments were given at 41.8 degrees C for 4 hours. Five patients received concomitant cyclophosphamide with hyperthermia. Compared to baseline (37 degrees C) conditions, there was a significant rise in pulse rate (P less than 0.001), a fall in diastolic pressure (P less than 0.02), and an increase in respiratory rate (P less than 0.001). Toxic effects included fatigue, extremity edema, diarrhea, nausea and vomiting, and respiratory depression in a patient with cerebral metastases. Compared to baseline values, there was a significant increase in serum glucose (P less than 0.02) and decreases in serum calcium (P less than 0.01) and phosphorus (P less than 0.01). Significant elevations in serum LDH and SGOT values occurred 24 hours following hyperthermia, suggesting hepatic sensitivity to heat.
|Cancer Treat Rep, Vol. 65 No. 3-4 pp 323-5
|ФИЗИОЛОГИ- ЧЕСКИЙ ОТВЕТ И ТОКСИЧНОСТЬ У ПАЦИЕНТОВ, КОТОРЫЕ ПЕРЕНЕСЛИ ПОЛНУЮ ГИПЕРТЕРМИЮ ТЕЛА ДЛЯ ЛЕЧЕНИЯ РАКА
|Семь пациентов с развитым раком прошли гипертермия всего тела с использованием костюма из нейлона и виниловой сетки. Лечение состояло в нагревании до 41,8 градусов С в течение 4 часов. Пять пациентов вместе с гипертермией получали циклофосфамид. По сравнению с исходными значениями (при 37 ° C) не наблюдалось значительного роста частоты пульса (P менее 0,001), падения диастолического давления (P менее 0,02) и увеличения частоты дыхания (P менее 0,001). Токсические эффекты у пациентов с церебральными метастазами включали в себя усталость, отеки конечностей, диарею, тошноту и рвоту, угнетение дыхания. По сравнению с исходными значениями, было отмечено значительное увеличение в сыворотке крови глюкозы (p менее 0,02) и снижение уровня кальция (p менее 0,01) и фосфора (P менее 0,01). Значительное повышение уровня сывороточного ЛДГ и АСТ произошло в течение 24 часов после гипертермии, что предполагает печеночную чувствительность к теплу.
E Friedenthal, J Mendecki, C Botstein, F Sterzer, M Nowogrodzki, R Paglione
SOME PRACTICAL CONSIDERA- TIONS FOR THE USE OF LOCALIZED HYPERTHERMIA IN THE TREATMENT OF CANCER
|Practical considerations in the selection and administration of microwave and RF induced hyperthermia in the treatment of various tumors are discussed. A thorough knowledge of the thermal properties of the tumor and its environment is required for the establishment of an effective therapeutic regimen. Examples of clinical observations illustrate the patients' general tolerance to the therapy and highlight the problems presented by some special cases. Possible ways of avoiding adverse effects during localized microwave induce heating of superficial tumors and RF heating of deep seated tumors are described.
|J Microw Power, Vol. 16 No. 2 pp 199-204
|НЕКОТОРЫЕ ПРАКТИЧЕСКИЕ СООБРАЖЕНИЯ ПО ИСПОЛЬЗО- ВАНИЮ ЛОКАЛЬНОЙ ГИПЕРТЕРМИИ В ЛЕЧЕНИИ РАКА
|Обсуждаются практические соображения при выборе и управлении микроволновой и радиочастотной индуцированной гипертермией в лечении различных опухолей. Для создания эффективного терапевтического режима необходимо доскональное знание тепловых свойств опухоли и ее среды. Примеры клинических наблюдений иллюстрируют общую толерантность пациентов к терапии и позволяют выделить проблемы, возникающие в некоторых особых случаях. Анализируются возможные способы избежать отрицательных последствий при локализованных микроволновых и радиочастотных нагреваниях поверхностных и глубинных опухолей.
N M Bleehen
HYPERTHERMIA IN THE TREATMENT OF CANCER
|The clinical use of hyperthermia for the treatment of cancer continues to be hampered by technical difficulties. Current methods of local heating do not give satisfactory heat profiles. The biological concepts behind the potentially successful use of this treatment modality are discussed together with a review of the advantages and disadvantages of the various techniques employed. Some clinical studies using microwaves and radiofrequency heating are reviewed.
|Br J Cancer Suppl, Vol. 5 No. pp 96-100
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА
|Клиническому применению гипертермии для лечения онкологических заболеваний по-прежнему препятствуют технические трудности. Современные методы локального нагрева не дают удовлетворительного распределения тепла. Биологические концепции, лежащие в потенциально успешном использовании этого метода лечения, обсуждаются вместе с обзором преимуществ и недостатков других используемых методов. Анализируются некоторые клинические исследования с использованием микроволного и радиочастотного нагрева.
R U, K T Noell, B T Worde, K T Woodward, R I Fishburn, L S Miller and others
HYPERTHERMIA IN CANCER TREATMENT: CURRENT AND FUTURE PROSPECTS
|The renewed interest in the possible use of localized hyperthermia in cancer therapy is prompted by two major realizations. The first is the radiobiological evidence indicating that there may be a significant advantage in the use of heat alone or combined with radiation therapy or chemotherapy to enhance the inactivation of tumor cells The second is that early clinical investigation with refractory malignant tumors at temperatures between 41 degrees C and 45 degrees C have shown tumor regression response rate over 70% without increasing normal tissue complication. A phase I/II study using electromagnetic hyperthermia immediately following administration of ionizing radiation was begun at Duke in the fall of 1976 to evaluate the response of normal tissues, the regression of cutaneous and subcutaneous tumors, and the feasibility of such combined modalities in therapeutic radiology. Each hyperthermia session consisted of 45 minutes at 42-43.5 degrees C 2-3 times per week immediately following radiotherapy. The radiation therapy fraction size was usually 2-3 Gy 3-5 times per week with a maximum total of 48 Gy. The 60+ patients treated to date have had squamous cell carcinoma, adenocarcinoma, malignant melanoma, plasmacytoma, liposarcoma, epithelioid sarcoma, and undifferentiated carcinoma. After more than 600 hyperthermia sessions, we have found: (1) local hyperthermia with microwave alone or in combination with ionizing radiation can be used with excellent normal tissue tolerance provided local tissue temperatures are carefully monitored and controlled; (2) a significantly higher level of preferential heat induction into tumor tissue is possible as compared to surrounding normal tissues; (3) repeated hyperthermia at 42-43.5 degrees C for 45 minutes per session immediately following radiation therapy yields favorable therapeutic results. Tumor regression response rate of over 70% was achieved without concomitant increase of normal tissue complication. Therefore, the potentially significant impact on clinical cancer therapy, whether of curative or palliative intent, by moderate thermotherapy is evident. Technical advances to optimize such treatment methods including R & D for delivering a known localized quantity of heat to tumors in any location in the body are expected to progress rapidly. The methods with most promising potential for inducing local thermotherapy are those involving the use of electromagnetic waves, e.g., radiofrequency energy, microwave energy, and ultrasound energy.
|Gan To Kagaku Ryoho, Vol. 9 No. 3 pp 343-56
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА: СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ
|Возобновившийся интерес к возможности использования локализованной гипертермия для лечения рака продиктована двумя основными соображениями. Первое - это радиобиологические доказательства того, что может быть достигнуто существенное преимущество в использовании нагревания в одиночку или в сочетании с лучевой терапией или с химиотерапией для повышения инактивации опухолевых клеток; второе: ранние клинические исследования нагревоупорных злокачественных опухолей при температурах от 41 ° С до 45 ° С показали, что частота ответа опухоли регрессией оказалась более 70% без осложнений для нормальных тканей. Фазы I / II исследований с использованием электромагнитной гипертермии сразу же после проведения ионизирующего излучения были начаты Дьюком осенью 1976 года для оценки реакции нормальных тканей, оценки регресса кожных и подкожных опухолей, а также целесообразности таких комбинированных методов в терапевтической радиологии. Каждая сессия гипертермии состояла из 45 минут при 42-43.5 ° С 2-3 раза в неделю сразу же после лучевой терапии. Доза лучевой терапии составляла, как правило, 2-3 Гр 3-5 раза в неделю с максимальной общей дозой 48 Гр. Более 60 пациентов имели плоскоклеточный рак, аденокарциному, злокачественную меланому, плазмоцитому, липосаркому, эпителиоидную саркому, и недифференцированные карциномы. После более чем 600 сессий гипертермии, мы установили: (1) локальная гипертермия микроволновой печью отдельно или в комбинации с ионизирующим излучением может быть использована в случае отличной нормальной толерантности тканей при условии, что локальные температуры тканей тщательно контролируются и управляются; (2) возникает значительно более высокая степень нагрева опухолевой ткани по сравнению с окружающей нормальной тканью; (3) повторная гипертермия при 42-43.5 ° С в течение 45 минут за сессию сразу же после лучевой терапии дает более благоприятный терапевтический результат. Ответ опухоли регрессией достигается свыше, чем в 70% случаев без сопутствующего увеличения осложнений в нормальных тканях. Таким образом, очевидно значительное влияние умеренной гипертермии на клиническое лечение рака, будь то применение лечебным или паллиативным. Ожидается, что технические средства для оптимизации таких методов лечения, включая R & D для доставки необходимого количество тепла локализованно к опухолям в любом месте тела, будут быстро прогрессировать. Наиболее перспективным для стимулирования местной термотерапии следует считать использование электромагнитных волн, например, радиочастотного диапазона, микроволновой энергии, а также ультразвуковой энергии.
F A Gibbs
"THERMAL MAPPING" IN EXPERIMENTAL CANCER TREATMENT WITH HYPERTHERMIA: DESCRIPTION AND USE OF SEMI-AUTOMATIC SYSTEM
|The regions of tumor which are least adequately heated during experimental hyperthermia treatments will most likely determine the ultimate probability of tumor control. Temperature inhomogeneity during local or regional hyperthermia is often marked, and stationary temperature probes yield very little information about the adequacy or inadequacy of tumor heating. Fine catheters can be placed through the tumor bearing region and temperatures recorded at various points within these catheters, thus yielding valuable data about temperature variations within the volume of interest. The "thermal mapping system" (TMS) described herein provides a method for remotely sampling these temperature variations in a semi-automatic manner in several catheters simultaneously. Its application in conjunction with a commercial hyperthermia system is described and clinical examples of its use and importance are provided.
|Int J Radiat Oncol Biol Phys, Vol. 9 No. 7 pp 1057-63
|"ТЕПЛОВОЕ ОТОБРАЖЕНИЕ" В ЭКСПЕРИМЕН- ТАЛЬНОМ ЛЕЧЕНИИ РАКА ГИПЕРТЕРМИЕЙ: ОПИСАНИЕ И ИСПОЛЬЗОВАНИЕ ПОЛУАВТОМА- ТИЧЕСКОЙ СИСТЕМЫ
|Те участки опухоли, которые в наименьшей степени нагреваются при экспериментальном применении лечения гипертермией, скорее всего, определяют возможность конечного контроля состояния опухоли. При местной или региональной гипертермии часто отмечается температурная неоднородность, стационарные датчики температуры дают мало информации о достаточности или недостаточности нагрева опухоли. Тонкие катетеры могут быть введены через опухоль в области суставов, при этом могут быть записаны температуры в различных точках внутри этих катетеров, что позволит обеспечить ценные данные об изменениях температуры в интересующем объеме. Метод "Тепловые системы отображения" (TMS), который здесь описан, обеспечивает удаленную выборку изменений температуры в полуавтоматическом режиме с нескольких катетеров одновременно. Описано его применение в сочетании с описанной коммерческой системой гипертермии, а также клинические примеры его использования и важности.
C Servadio, Z Leib
HYPERTHERMIA IN THE TREATMENT OF PROSTATE CANCER
|Hyperthermia - the sustained heating of tissues to temperatures of 42 degrees C to 43.5 degrees C - increasingly is being studied by scientists as a new tool to destroy cancer cells, either alone or in conjunction with other well established forms of treatment, such as radiotherapy and chemotherapy. Many studies on tissue cultures, on animals and also on humans, have established the fact that this new nonconventional adjuvant form of treatment is actually effective. Progress is being made in the development of the necessary technology for delivering the desired and controlled form of heat to the diseased site, while protecting the surrounding healthy tissues from irreversible damage. Initial clinical trials in this direction are very promising and seem to offer new avenues in the methods of treatment for cancer of the prostate.
|Prostate, Vol. 5 No. 2 pp 205-11
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА ПРЕДСТАТЕЛЬ- НОЙ ЖЕЛЕЗЫ
|Гипертермия - устойчивый нагрев тканей до температуры 42 градусов до 43,5 градусов С - с возрастающим интересом изучается учеными в качестве нового инструмента для уничтожения раковых клеток, либо самостоятельно, либо совместно с другими хорошо известными формами лечения, такими как лучевая терапия и химиотерапия. Многие исследования на культурах тканей, на животных, а также на людях установили факт, что эти новые нетрадиционные формы профилактического лечения на самом деле эффективны. Достигнут прогресс в разработке необходимых технологий для доставки на больное место желаемого тепла и управления им, с защитой при этом окружающих здоровых тканей от необратимого ущерба. Первоначальные клинические испытания в этом направлении являются весьма перспективными и, похоже, что они дают новое решение в методах лечения рака предстательной железы.
D S Shimm, L E Gerweck
HYPERTHERMIA IN THE TREATMENT OF CANCER
|Hyperthermia for the treatment of cancer was first used by Coley (1) in this country in 1893. After a period of eclipse, hyperthermia has enjoyed a recent surge in interest on the part of engineers, biologists, and clinicians. Research into the biology of hyperthermia has concentrated on the physiologic conditions that alter response to hyperthermia, and the phenomenon of thermo-tolerance, whereby cells surviving an initial heat treatment sustain transient resistance to subsequent heat treatments. The response to hyperthermia is increased in the presence of combined acute hypoxia and glucose deprivation (2), chronic hypoxia alone (3), or low cells pH (4).
|Ann Intern Med, Vol. 100 No. 5 pp 757-9
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА
|Гипертермию. для лечения рака впервые использовал Колли (1) в этой стране в 1893 году. После периода забвения, гипертермия недавно получила всплеск интереса со стороны инженеров, биологов и врачей. Исследования биологии гипертермии сосредоточились на физиологических условиях, которые изменяют ответ организма на гипертермию, и на явлении термо-допуска, в результате которого клетки, которые выжили при начальной термической обработке, поддерживают переходное сопротивление при последующих термообработках. Отклик на гипертермию повышается в присутствии комбинированной острой гипоксии при лишении глюкозы (2), при одной хронической гипоксии (3) или при низком уровне рН клетки (4).
Dr. Donald Cole
|The ideal part of this treatment to me, on a theoretical basis, is that it answers two of the deficiencies in most cancer therapies. One, it is not mutilating, and it is non-toxic. Secondly, you are treating cancer as though it is a disease of the body rather than as though it is just a disease of the local primary tumor site, which it really is not. Because if it were, most of the patients that do develop cancer would be cured whereas in reality it is just the opposite.
|ПОЛНАЯ ГИПЕРТЕРМИЯ ТЕЛА
|Для меня идеальным свойством этого вида лечения, на теоретической основе, является то, что он отвечает двум известным недостаткам большинства методов лечения рака. Первое: метод не калечит, т.к. он не токсичен. Второе: вы лечите рак так, как будто это болезнь всего тела, а не так, как будто это болезнь местной первичной опухоли, хотя на самом деле это не так. Ведь если бы было так, чтобы большая часть пациентов, у которых развивается рак, бы быть вылечена, однако, в действительности все как раз наоборот.
J R Stewart, F A Gibbs
HYPERTHERMIA IN THE TREATMENT OF CANCER. PERSPECTIVES ON ITS PROMISE AND ITS PROBLEMS
|The potential for the use of hyperthermia in the treatment of cancer is based on a strong and compelling biologic rationale. In the laboratory it has been shown in quantitative assays both in vitro and in vivo that (1) hyperthermia is cytotoxic to tumor cells as a function of time at temperatures above 42 degrees C; (2) cytotoxicity is relatively high for radioresistant S-phase cells and for cells that are nutritionally deprived and acidotic, conditions one might expect in regions of tumors containing large numbers of radioresistant hypoxic cells; and (3) heat is a radiosensitizer. Clinical study is hampered by less than optimal physical heating methods and the need for invasive thermometry. Ultrasonic and electromagnetic approaches each have limitations and advantages. In spite of technical limitations, efficacy has been shown for superficial tumor sites treated by local hyperthermia. Studies are underway investigating the more complicated problem of deep regional hyperthermia. Although whole body hyperthermia has the attractive capability of treating metastatic as well as more localized cancer, it is toxic therapy and its role in treatment remains undefined. Research advances in equipment design and treatment optimization are needed; however, there are studies underway utilizing existing methods and rationale which should further clarify the potential clinical usefulness of regional hyperthermia in combined approach to cancer therapy.
|Cancer, Vol. 54 No. 11 Suppl pp 2823-30
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА. МНОГООБЕ- ЩАЮЩИЕ ПЕРСПЕКТИВЫ И ПРОБЛЕМЫ
|Потенциал в использования гипертермии для лечении рака основан на сильных и убедительных биологических обоснованиях. В лаборатории при количественных анализах, как в пробирке и в естественных условиях, было показано, что (1) гипертермия, как функция времени при температуре выше 42 градусов С, производит цитотоксическое действие на опухолевые клетки ; (2) цитотоксичность гипертермии высока для радиорезистентных S-фазе клеток и для ацидотических клеток, лишенных питания, этого можно ожидать в участках опухолей, содержащих большое количество радиорезистентных гипоксических клеток, и (3) нагревание является радиосенсибилизатором. Клинические исследования сдерживаются недостаточностью физических средств нагревания и необходимостью инвазивной термометрии. Ультразвуковые и электромагнитные подходы имеют и ограничения, и преимущества. Несмотря на технические ограничения, их эффективность была показана для лечения локальной гипертермией поверхностных участков опухоли. Ведутся исследования по более сложной задаче глубокой региональной гипертермии. Хотя общая управляемая гипертермия имеет привлекательные возможности лечения метастатического, а также более локализованного вида рака, именно токсичная терапиия и ее роль в лечении остается неопределенной. Необходимы сдвиги в области дизайна оборудования и оптимизации лечения. По использованию и обоснованию существующих методов ведутся исследования, которые должны способствовать уточнению потенциальной клинической полезности региональной гипертермии в комбинированном подходе к терапии рака.
HYPERTHERMIA IN THE TREATMENT OF CANCER
|The expectation that hyperthermia would be effective in the treatment of cancer is attributable to a theoretical viewpoint based upon biological studies. Cancer cells, which characteristically are hypoxic with poor nutrition and low pH, are sensitive to temperatures over 42.5 degrees C. This is the theoretical basis which assures the effectiveness of hyperthermia when used in combination with radiation therapy. Previous clinical studies have shown that a combination hyperthermia and radiation therapy is an effective treatment for superficial tumors, thus expanding the range of cancer therapy. When used for deeply seated cancer, this combination enhances the efficiency of therapy. It is, however, necessary to improve the heating techniques and methods of thermometry. Fundamental studies are now being actively pursued in respect of combined hyperthermia and chemotherapy. However, inadequacy of clinical material hinders evaluation. The combination of whole-body hyperthermia with anti-cancer agents presents so far, unsolved problems, such as determination of applicable anatomical regions and prevention of complications.
|Gan No Rinsho, Vol. 32 No. 1 pp 101-5
|ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА
|Ожидание того, что гипертермия будет эффективна при лечении рака, с теоретической точки зрения основано на биологических исследованиях. Раковые клетки, которые гипоксически характерны плохим питанием и низким рН, оказались чувствительны к температуре выше 42,5 градусов С. Это теоретическая база, которая обеспечивает эффективность гипертермии при использовании ее в комбинации с лучевой терапией. Предыдущие клинические исследования показали, что комбинация гипертермии и лучевой терапия является эффективным средством для лечения поверхностных опухолей, тем самым расширяется спектр методов терапии рака. При использовании для глубоко сидящих раковых опухолей, эта комбинация повышает эффективность терапии. Однако, для улучшения нагрева необходимы приемы и методы термометрии. Фундаментальные исследования в настоящее время активно проводятся в отношении совместного применения гипертермии и химиотерапии. Тем не менее, недостаточность клинического материала препятствует оценке результатов. Сочетание гипертермии всего тела с противораковыми агентами представляет собой ряд не решенных проблем, таких как определение применимости в различных анатомических областях и предотвращение осложнений.
K Nakajima, H Hisazumi, S Tokunaga, O Kumaki, M Nitta, Y Saito
COMBINED TREATMENT OF 8 MHz RADIOFRE- QUENCY HYPERTHERMIA AND IRRADIATION IN A PATIENT WITH MEDIASTINAL METASTASES OF RENAL CANCER
|A combined therapy of irradiation and 8 MHz radiofrequency hyperthermia using the Thermotron-RF Model 8 was performed on a patient with mediastinal metastasis of renal cancer. The patient was a 74-year-old male, who received left transperitoneal nephrectomy for left renal tumor in December, 1982. Histology report indicated clear cell carcinoma of the kidney. He noticed puffy face and dyspnea in April, 1984. A CT scan showed a mediastinal tumor 57 X 43 X 120 mm in size and right pleural effusion. Aspiration biopsies revealed metastatic adenocarcinoma of the mediastinal lymph nodes. The combined therapy of irradiation and 8 MHz radiofrequency hyperthermia was started in July, 1984. He was irradiated with daily 2.0 Gy, 5 times a week and was heated twice a week within one hour after each irradiation, totally 50 Gy of irradiation and 14 sessions of hyperthermia. After the treatment, 69% tumor regression and disappearance of pleural effusion were obtained. The combined therapy with 28.8 Gy of irradiation and 7 sessions of hyperthermia was added for the regrowth of the tumor in February, 1985. A 30% of tumor regression was achieved, however, there was no improvement of the dyspnea or pleural effusion. He died on April 8, 1985
|Hinyokika Kiyo, Vol. 32 No. 3 pp 441-7
|КОМБИНИРО- ВАННОЕ ЛЕЧЕНИЕ БОЛЬНОГО РАКОМ ПОЧКИ С МЕТАСТАЗАМИ СРЕДОСТЕНИЯ С ПОМОЩЬЮ РАДИОЧАС- ТОТНОЙ ГИПЕРТЕРМИИ ЧАСТОТОЙ 8 МГц И ОБЛУЧЕНИЯ
|Комбинированная терапия облучением и радиочастотной гипертермией 8 МГц с использованием аппарата Thermotron-RF 8 модели была сделана пациенту со средостением метастазов рака почки. Пациентом был 74-летний мужчина, которому сделана нефрэктомия левой почечной опухоли в декабре 1982 года. Гистология ясно показала рак почки. Он заметил одутловатое лицо, одышку в апреле 1984 года. Компьютерная томография показала опухоль средостения размером 57 X 43 X 120 мм и жидкость в правой плевральной полости. Данные биопсии показали метастатическую аденокарциному лимфатических узлов средостения. Комбинированная терапия облучением и радиочастотной гипертермией 8 МГц была начата в июле 1984 года. Он облучался дозой 2,0 Гр ежедневно, 5 раз в неделю и подвергался гипертермии два раза в неделю в течение одного часа после каждого облучения, всего 50 Гр облучения и 14 сеансов гипертермии. После лечения удалось добиться 69% регрессии опухоли и исчезновения плеврита. Дополнительно проведена комбинированная терапия с 28,8 Гр облучения и 7 сеансами гипертермии из-за роста опухоли в феврале 1985 года. Была достигнута 30% регрессия опухоли, однако, не было никакого улучшения по поводу одышки и плеврального выпота. Он умер 8 апреля 1985 года.
EXPERIMENTAL STUDIES ON THERMOTOLE- RANCE IN HYPERTHERMIA TREATMENT OF CANCER
|Thermotolerance was investigated in hyperthermia using FM3A cells in vitro and in vivo. FM3A cells were heated at 42.0 degrees C, 43.0 degrees C and 44.0 degrees C and the survival rate of the cells was decreased in this order. In in vitro experiments, thermotolerance induced by heating at 43.0 degrees C for 30 min reached at maximum, when the heating interval was 12 hr and thermotolerance induced by heating at 44.0 degrees C for 30 min reached at maximum, when the heating interval was 12 to 24 hr. In in vivo experiments, thermotolerance induced by heating at 42.0 degrees C, 43.0 degrees C and 44.0 degrees C continued for 48 hr after initial heating and disappeared after 96 hr. In the repeated hyperthermia experiments, 7 times with 24 hr interval heating or 4 times with 48 hr interval heating did not show the significant inhibition of tumor growth as compared with the control group at 42.0 degrees C, 43.0 degrees C and 44.0 degrees C. However, twice with 96 hr interval heating indicated the significant inhibition of tumor growth at 42.0 degrees C, 43.0 degrees C and 44.0 degrees C. From these results it is suggested that hyperthermia treatment should be repeated after the disappearance of thermotolerance.
|Nippon Geka Gakkai Zasshi, Vol. 88 No. 6 pp 663-74
|ЭКСПЕРИМЕН- ТАЛЬНЫЕ ИССЛЕДОВАНИЯ ТЕРМОТОЛЕ- РАНТНОСТИ ПРИ ЛЕЧЕНИЯ РАКА ГИПЕРТЕРМИЕЙ
|Была исследована термотолерантность раковых FM3A клеток к гипертермии в пробирке и в естественных условиях. FM3A клетки нагревались до 42,0 ° С, 43,0 ° С и 44,0 ° С и выживаемость клеток снижалась в этом же порядке. В экспериментах в пробирке, термотолерантность, индуцированная путем нагревания при 43,0 ° С в течение 30 мин, составляла 12 ч, а термотолерантность, индуцированная путем нагревания при 44,0 ° С в течение 30 мин, составляла от 12 до 24 час. В экспериментах в естественных условиях, термотолерантность индуцированная путем нагревания при 42,0 ° С, 43,0 ° С и 44,0 ° С продолжалась в течение 48 часов после первоначального нагрева и исчезла через 96 час. При повторении экспериментов с гипертермией, в 7 случаях с интервалом нагревания 24 час или в 4 случаях с интервалом нагревания 48 ч не было получено значительного торможения роста опухоли по сравнению с контрольной группой на 42,0 ° С, 43,0 ° С и 44,0 ° С. Однако, дважды нагревание интервалом 96 ч показало значительное торможение роста опухоли на 42,0 ° С, 43,0 ° С и 44,0 ° С. Из этих результатов можно сделать вывод, что лечение гипертермией следует повторять после исчезновения термотолерантности.
S B Field
1985 DOUGLAS LEA MEMORIAL LECTURE. HYPERTHERMIA IN THE TREATMENT OF CANCER
|There are sound biological reasons for using hyperthermia in the treatment of malignant disease. This review includes a discussion of this rationale and describes effects of hyperthermia either given alone or in combination with ionising radiation to cells in vitro, tumours or normal tissues. Topics discussed include thermotolerance, step-down sensitisation, fractionation, re-treatment of previously irradiated sites, thermal enhancement ratio and thermal dose. Problems of heat delivery and temperature measurement are considered and the current status of clinical studies is stated briefly.
|Phys Med Biol, Vol. 32 No. 7 pp 789-811
|МЕМОРИАЛЬНАЯ ЛЕКЦИЯ ДУГЛАСА ЛИ 1985 ГОДА. ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА
|Есть серьезные биологические причины для использования гипертермии в лечении злокачественных заболеваний. Данный обзор включает в себя обсуждение этого обоснования и описывает эффект гипертермии, проводимой либо отдельно, либо в комбинации с ионизирующим облучением в пробирке клетки, опухоли или нормальной ткани. Темы обсуждения включают термотолерантность, понижение чувствительности, фракционирование, повторное лечение облученных ранее участков, коэффициент термического расширения и тепловые дозы. Кратко рассматриваются проблемы доставки тепла, измерения температуры и текущий статус клинических исследований.
R. D. Issels
APPLICATION OF HYPERTHERMIA IN THE TREATMENT OF CANCER
|Physicians, biologists and physicists present their recent work in the field of hyperthermia with regard to both its application and its combination with radiation and chemotherapy. Current technical possibilities, clinical management and major aspects of its use for superficial and deep-seated tumors are pointed out. The main topics discussed are: changes of metabolism and microcirculation under heat conditions, the biological interaction of heat with X-rays and several chemotherapeutic agents, and the most recent clinical data from different institutions on the combined application in the treatment of cancer.
|Recent Results Cancer Res, Vol. 107 No. pp 1-277
|ПРИМЕНЕНИЕ ГИПЕРТЕРМИИ ДЛЯ ЛЕЧЕНИЯ РАКА
|Врачи, биологи и физики представляют свои последние работы в области гипертермии как с точки зрения ее отдельного применения, так и ее комбинации с лучевой и химиотерапией. Перечислены существующие технические возможности, клинические руководства и основные аспекты ее использования для поверхностных и глубинных опухолей. Основными темами обсуждения являются: изменения метаболизма и микроциркуляции под воздействием высокой температуры, биологические взаимодействия нагревания с Х-лучами и некоторыми химиотерапевтическими препаратами, а также самые последние клинические данные из различных учреждений по комбинированному применению гипертермии в лечении онкологических заболеваний.
J van der Zee, A D Treurniet-Donker, S K The, P A Helle, J J Seldenrath, J H Meerwaldt and others
LOW DOSE REIRRADIATION IN COMBINATION WITH HYPERTHERMIA: A PALLIATIVE TREATMENT FOR PATIENTS WITH BREAST CANCER RECURRING IN PREVIOUSLY IRRADIATED AREAS
|Ninety-seven patients with breast cancer recurring in a previously irradiated area (mean dose 44 Gy) were reirradiated in combination with hyperthermia and had evaluable tumor responses. In the reirradiation series, radiotherapy was given twice weekly in most patients, with a fraction size varying from 200 to 400 cGy, the total dose varying from 8 to 32 Gy. Hyperthermia was given following the radiotherapy fractions. The combined treatment resulted in 35% complete and 55% partial responses. Duration of response was median 4 months for partial response and 26 months for complete response, respectively. The median survival time for all patients was 12 months. Acute skin reaction was mild, with more than moderate erythema in only 14/97 patients. Thermal burns occurred in 44/97 patients, generally at sites where pain sensation was decreased, and therefore they did not cause much inconvenience. In the 19 patients who survived more than 2 years, no late radiation damage was observed. When patients who received a "high dose" (greater than 29 Gy and hyperthermia) were compared with those who received a "low dose" (less than 29 Gy and hyperthermia), a higher complete response rate was observed in the high dose group (58% vs. 24%), whereas no difference in acute toxicity was found. We conclude that reirradiation with 8 x 4 Gy in combination with hyperthermia twice weekly is a safe, effective and well tolerated method for palliative treatment of patients with breast cancer recurring in previously irradiated areas.
|Int J Radiat Oncol Biol Phys, Vol. 9 No. 7 pp 1057-63
|ПОВТОРНОЕ ОБЛУЧЕНИЕ МАЛЫМИ ДОЗАМИ В КОМБИНАЦИИ С ГИПЕРТЕРМИЕЙ: ПАЛЛИАТИВНОЕ ЛЕЧЕНИЕ ДЛЯ БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ
|Девяносто семь пациентов с раком молочной железы повторяющимся в ранее облученной области (средняя доза 44 Гр) были вновь облучены в комбинации с гипертермией и был произведен анализ ответов опухоли. В серии повторных облучений лучевая терапия производилась два раза в неделю у большинства пациентов с различным размером опухоли доза была от 200 до 400 сГр, суммарная доза варьировалась от 8 до 32 Гр. Гипертермия была дана после лучевой терапии. Комбинированное лечение привело к 35% полных и 55% частичных ответов. Продолжительность ответа, в среднем, 4 месяца для частичного ответа и 26 месяцев для полного ответа, соответственно. Медиана выживаемости для всех пациентов была 12 месяцев. Острая реакция кожи была мягкая, с более чем умеренной эритемой только у 14 из 97 пациентов. Термические ожоги произошли в 44/97 пациентов, как правило, на участках, где болевых ощущения снизилась, и поэтому они не вызывают особых неудобств. У 19 пациентов, которые прожили более 2 лет, радиационных повреждений обнаружено не было. Когда пациенты, которые получили "большая доза" (более 29 Гр и гипертермия), сравнивались с теми, кто получил "малая доза" (менее 29 Гр и гипертермия), более высокий полный курс реакция наблюдалась в группе с высокой дозой (58% против 24%), однако, никакой разницы в острой токсичности не было найдено. Мы заключаем, что повторяемое облучение с 8 х 4 Гр в сочетании с гипертермией два раза в неделю является безопасным, эффективным и хорошо переносимым методом паллиативного лечения больных раком молочной железы, повторяющимся в ранее облученных районах.
P R Dunlop, G C Howard
HAS HYPERTHERMIA A PLACE IN CANCER TREATMENT?
|Long before ionising radiations were discovered, attempts were made to exploit elevated temperatures to control malignant tumours. At irregular intervals over the last 100 years, hyperthermia has been suggested for use in cancer therapy but has never become established. There is little doubt that heat alone can destroy tumours; and it can enhance the anti-cancer effects of radiation and chemotherapeutic agents. Laboratory and in vivo animal data provide hyperthermia with a strong biological rationale, which gives the more recent revival of interest a sounder base than previously. The exact science of hyperthermia, however, is still in its infancy, and how it should be employed to its best advantage in human cancer therapy remains illusive. We review the current position of hyperthermia in clinical cancer management and look to see what achievements are likely in the near future.
|Clin Radiol, Vol. 40 No. 1 pp 76-82
|ИМЕЕТ ЛИ МЕСТО ГИПЕРТЕРМИЯ В ЛЕЧЕНИИ РАКА?
|Задолго до того как были обнаружены ионизирующие излучения, предпринимались попытки использовать повышенные температуры для воздействия на злокачественные опухоли. Через разные промежутки времени на протяжении последних 100 лет гипертермия предлагалась для использования в терапии рака, но так и не стала принятой. Существует некоторое сомнение, что только одна гипертермия может разрушить опухоль, что она может улучшить противораковый эффект радиации и химиотерапевтических средств. И в лаборатории, и в естественных условиях данные по гипертермии на животных обладают сильным биологическим основанием, которое дает толчок недавнему возрождению большего интереса к гипертермии, чем ранее. Точное научное обоснование гипертермии, однако, все еще находится в зачаточном состоянии, и как она должна быть использована наилучшим образом в терапии рака человека, остается загадкой. Мы рассматриваем текущее положение гипертермии в клиническом лечении рака и анализируем, какие достижения, наиболее вероятны в ближайшем будущем.
N Schwegler, M Notter, W Burkard
HYPERTHERMIA - A NEW ELEMENT IN CANCER TREATMENT
|The efficacy of radiation therapy combined with local hyperthermia is demonstrated by three case studies. Mode of action and problems are discussed and published results reported. Human tumour cells obtained of biopsies from our patients before the onset of treatments were investigated. The short time cell cultures were treated either with hyperthermia or irradiation alone or with combinations under the same conditions as the clinical treatments. We could clearly demonstrate that cell cultures of human origin respond to irradiation or hyperthermia. But the effect was limited and only cultures treated with combined modalities did not relapse. There is hope that mega-voltage radiation complemented with hyperthermia have a similar effect as high-LET-radiation. Side effects have been moderate so far using an extended clinical use.
|Schweiz Rundsch Med Prax, Vol. 78 No. 34 pp 897-904
|ГИПЕРТЕРМИЯ - НОВЫЙ ЭЛЕМЕНТ В ЛЕЧЕНИИ РАКА
|Эффективность лучевой терапии в сочетании с локальной гипертермией показана на трех тематических исследованиях. Обсуждаются методы воздействия и другие проблемы, сообщается об опубликованных результатах. Человеческие опухолевые клетки, полученные с помощью биопсии от наших пациентов были исследованы нами до начала лечения. На протяжении короткого времени клеточные культуры лечились либо гипертермией, либо облучением по отдельности или с помощью их комбинации при тех же условиях, как и при стационарном лечении. Мы могли бы четко показать, что культуры клеток человеческого происхождения реагируют на облучение или гипертермию. Но этот эффект был ограниченным и только культуры, обработанные с помощью их комбинации не дали рецидивов. Существует надежда, что мега-напряженное излучения дополненное гипертермией даст такой же эффект, как и высокое ЛПЭ излучение. Побочные эффекты были умеренными до сих пор с использованием расширенного клинического использования.
HISTORICAL ASPECTS OF HYPERTHERMIA IN CANCER THERAPY
|The use of hyperthermia in cancer therapy had its origin in antiquity. Recently, some have hailed hyperthermia as the new fourth method of cancer therapy, and others have branded the treatment as "quackery" surrounded by mysticism, ignorance, and confusion. The American Cancer Society has been ambivalent, first placing it on its infamous unproven cancer therapy methods list, along with Laetril, Hoxey's cancer pills, hot water enemas, snake root oil, and other various and sundry "cancer cures." A few years ago the Society removed it from its list after deciding that hyperthermia may indeed have a place in future cancer therapy. This brief historical review highlights some of the most important early clinical discoveries and basic laboratory studies, which should help convince even the most avid skeptics of hyperthermia of the necessity of continuing the study of this most controversial form of cancer therapy.
|Radiol Clin North Am. 1989 May; 27(3):481-8
|ИСТОРИЧЕСКИЕ АСПЕКТЫ ГИПЕРТЕРМИИ В ЛЕЧЕНИИ РАКА
|Использование гипертермии в лечении рака имеет свое начало в древности. В последнее время некоторые приветствовали гипертермию в качестве нового, четвертого метода лечения рака, тогда как другие заклеймили это лечение как "шарлатанство", которое окружено мистикой, невежеством и путаницей. Американское онкологическое общество было амбивалентно, сначала разместив его в своем печально известном списке недоказанных методов терапии рака, наряду с таблетками от рака Laetril и Hoxey, клизмами с горячей водой, маслом корня змеи и другими различными методами "универсальной терапии рака". Несколько лет назад общество удалило его из своего списка, решив, что гипертермия в будущем может действительно применяться для терапии рака. Этот краткий исторический обзор освещает некоторые из наиболее важных ранних клинических открытий и основные лабораторные исследования, которые должны помочь убедить даже самых придирчивых скептиков гипертермии в необходимости продолжать изучение этого самого спорного метода терапии рака.
J L Huang
APPLICATION OF LOCALIZED HYPERTHERMIA SOLIDIFICATION COMBINED WITH SURGERY IN THE TREATMENT OF LIVER CANCER: A PERORT OF 34 CASES
|In 1980, we developed a Localized Hyperthermia Solidification Apparatus (LHSA), which can produce localized controllable hyperthermia and solidify the tumor tissues. Without the interference of the Corporal and visceral physiology. Animal experiments and pathological study proved it an effective and Safe means to deal with visceral cancers. From 1982 to 1988, 34 cases of liver cancer patients received the LHSA therapy combined with operations. The therapy was effective in 86.19% of cases, and the longest survival time was 5 years.
|Zhonghua Wai Ke Za Zhi, Vol. 27 No. 9 pp 535-574
|ДОКЛАД О 34 СЛУЧАЯХ ПРИМЕНЕНИЯ ЛОКАЛЬНОЙ ГИПЕРТЕРМИИ В СОЧЕТАНИИ С ХИРУРГИЧЕСКИМ ЛЕЧЕНИЕМ РАКА ПЕЧЕНИ
|В 1980 году мы разработали аппарат для локальной гипертермия (LHSA), который может осуществлять локализованную управляемую гипертермию и укреплять опухолевые ткани. Без вмешательства телесной и висцеральной физиологии. Эксперименты на животных и патологические исследования доказали эффективность и безопасность этого средства борьбы с раком внутренних органов. С 1982 по 1988 год в 34 случаях больные раком печени получили терапию аппаратом LHSA в сочетании с операциями. Терапия была эффективной в 86,19% случаев, при этом самая длинная продолжительность дальнейшей жизни составила 5 лет.
A Giori, C Campisi, M Sperandio
POSSIBILITY OF USING INTRACAVITARY PERFUSION HYPERTHERMIA IN THE TREATMENT OF GASTRIC CANCER: AN STUDY OF ITS LOCAL AND SYSTEMIC EFFECTS
|The selective lethal effect of heat on neoplastic cells has been demonstrated by several experiments "in vitro" and "in vivo". In this paper the authors report their experience on endocavitary-hyperthermic perfusion of the stomach, performed with a hyperthermic-perfusion system invented and built by them. 12 rabbits were submitted to hyperthermic perfusion of the stomach at 42.5 C for a period of 50 minutes under general anesthesia. Three other rabbits were treated with normothermic perfusion for a further control. Rectal temperature was monitored during perfusion and gastric pH was evaluated after treatment by a gastrectomy. Neither death nor major complications were observed during and after treatment and physiologic functions were maintained. Animals were sacrificed at different times from the treatment and macroscopic and microscopic exams of the principal organs were performed. Edema of the gastric wall was present in rabbits killed after a short time from treatment, while it was absent in animals sacrificed after a longer time; in these animals normal aspect of gastric glands and no fibroblastic activity was evident. The authors consider the possibility of employing this treatment in curing advanced gastric cancer, eventually associated with hyperthermic perfusion of abdominal cavity.
|Ann Ital Chir, Vol. 60 No. 6 pp 555-9
|ВОЗМОЖНОСТЬ ИСПОЛЬЗОВА- НИЯ ВНУТРИПОЛОСТ- НОЙ ПЕРФУЗИОННОЙ ГИПЕРТЕРМИИ В ЛЕЧЕНИИ РАКА ЖЕЛУДКА: ИССЛЕДОВАНИЕ ЕЕ ЛОКАЛЬНЫХ И СИСТЕМНЫХ ЭФФЕКТОВ
|Селективно летальное действие тепла на опухолевые клетки было продемонстрировано на нескольких экспериментах "в пробирке" и "в естественных условиях". В данной работе авторы сообщают о своем опыте по внутриполостной гипертермии системы кровоснабжение желудка, выполненной с помощью гипертермически-перфузионной системы, которую они изобрели и построили. 12 кроликам была произведена гипертермия системы кровоснабжения желудка при 42,5 С в течение 50 минут под общим наркозом. Троих других кроликов лечили нормотермической перфузией для последующего сравнения. Во время перфузии контролировалась ректальная температура, а рН желудка оценивалась после проведения гастрэктомии. Ни смерти, ни серьезных осложнений во время и после лечения не наблюдалось, физиологические функции были сохранены. Животные были умерщвлены в разное время, затем был выполнен макро- и микроскопический анализ их главных органов. У кроликов, забитых через короткий промежуток времени после лечения, был обнаружен отек стенки желудка, в то же время он отсутствовал у животных, забитых после более длительного времени, у этих животных нормально функционировали желудочные железы и не было отмечено никакой активности фибробластов. Авторы считают возможным применение этого метода в лечении распространенного рака желудка, который, в конечном счете, связан с гипертермией перфузии брюшной полости.
1. The effectiveness of hyperthermia is already proved sufficiently. About this may indicate, for example, the slogan that I recently met at the site of one Cancer Institute in Los Angeles:What is written above is, in essence, THE DIAGNOSIS of the problem of using hyperthermia in therapeutic practice (as of 1989). Further, as it should be in medicine, problem should be followed by its THERAPY. This "therapy" I will also set out in separate paragraphs:
"Hyperthermia, one of the most effective and low side effects cancer treatment available worldwide!"
2. In most cases, the test was done only in local hyperthermia. Application of whole hyperthermia in cancer treatment is still in its infancy.
3. The use of hyperthermia therapy in medical practice hampered by the complete absence of theoretical justification.
4. In general, the practice of hyperthermia in many experiments proved to be effective, but still needed further investigation.
5. Until 1989, I HAVE NOT FOUND A SINGLE PROPOSAL on the use of hyperthermia for the treatment of human AIDS.
6. The wide application of hyperthermia in medicine require further develop effective ways to control the temperature inside the tissue the patient.
7. In the world there is practically no apparatus for implementing an whole electromagnetic hyperthermia. Available to the general human experience hyperthermia, usually boiled down to only heat the body in hot water without immersion of the head. And that, by and large, WHOLE body hyperthermia is not (see below point 3), and therefore does not guarantee cure...
8. My proposal of 23 May 1989 on the treatment of AIDS by a full body hyperthermia (like microwave) with bringing the body temperature to 42-44 degrees Celsius HAS THE WORLD NOVELTY ON THE ABOVE DATE. That's what I wanted to prove to V. Vetvin back in 1989. However, I did not have such an opportunity. By the way, 06/25/90 professor Rakhmanova A.G., the main infectionist of Leningrad, pointed out my prioritet in this question compared with Robert Gallo, who in 1990 for the treatment of AIDS patients warmed to 42 degrees Celsius with the cooling of the brain.
9. From the history of the use of full body hyperthermia for cancer therapy the most attention deserves an article  with the date of priority of March 1, 1981. This article describes the positive outcome of the use of full body hyperthermia to 41.8 degrees during 4 hours. It was a full body hyperthermia using a costume made of nylon and vinyl mesh. It should be noted that the maximum temperature was clearly not sufficient. However, this article gives us the priority date to the very idea of using full body hyperthermia against cancer.
10. Authorship of the idea of full body hyperthermia for the treatment of a broad class of diseases belongs to the ancient Greek philosopher Parmenides, a statement which I put as an epigraph to this article. Apparently, the law of world harmony was known to him, like Anaxagoras, from an ancient times.
1. For wide application of hyperthermia in the treatment of cancer, AIDS, and a number of other diseases is necessary to construct a good theory, which will explain the effectiveness of hyperthermia. This theory is almost fully built and presented in a number of my articles. The beginning of this path follows from my law of world harmony, more precisely, from the my conclusions from it, which provided me the basis for the decoding scheme of the program the immune defense of the person (PID) and human immunodeficiency virus (HIV) scheme. Only after these schemes discovering I proposed in 1989 a method for treating cancer and AIDS. All of humanity was doing exactly the opposite: It sought a cure in the absence of disease theory.
2. The acceleration in matters of treatment of cancer, AIDS and other diseases can occur only after the humanity will replace its "paradigm" in relation to these, the most difficult for human diseases. The current paradigm considers that these diseases are under control of biologists and virologists that the reasons for them are at the molecular level. The new paradigm is that THESE DISEASES DO NOT HAVE ANY TANGIBLE CARRIER OF. These diseases are only parasitic programs that absolutely can not be seen through a microscope. Therefore, all knowledge on infectious diseases, knowledge of virologists were powerless here. You must open a new medical direction, such as "Diseases of CHAIN REACTION-TYPE".
3. Local hyperthermia can not be an effective treatment for AIDS and cancers due to the fact that diseases such as "chain reaction" always resume its operation from those areas of the body that were not subjected to heat treatment. Only a complete heat treatment of the body can stop such disease.
4. It has already been noted above (in particular, in ) that hyperthermia is a "clean" method of treatment without side effects. When a new paradigm, which I mentioned above, will be formally adopted, it becomes clear to all: when whole-body hyperthermia is used correctly, no any additional treatment, such as radiation or chemotherapy, will be needed, full hyperthermia is self-sufficient.
5. Based on solid state physics detailed justification the effectiveness of whole-body hyperthermia against AIDS set out by me in the article three «Diseases of "Chain Reaction-type"», as well as in the article one «Cancer and AIDS can be defeated by the "method of black drawer"?». Based on energetic principles this rationale is set out by me in the «ENERGY AND AIDS» article. After the changing of the above mentioned paradigm of these rationales will be enough to effectively move forward.
«When I became interested in the problem of AIDS, I firstly began to study "the work scheme" of this disease. On this way, I firstly decoded the scheme of the program of immune system defence of the human (PID), and then I decoded the working scheme of human immunodeficiency virus (HIV). According to data, which I have, NOBODY IN THE WORLD DID THIS BEFORE ME.»11/13/2011   Segrim